Noscapine is an opioid alkaloid derived from the opium poppy (Papaver somniferum). It is a non-addictive antitussive (cough suppressant) used to treat persistent, non-productive cough. Noscapine's antitussive effects appear to be primarily mediated by its σ–receptor agonist activity. Evidence for this mechanism is suggested by experimental evidence in rats. Pretreatment with rimcazole, a σ-specific antagonist, causes a dose-dependent reduction in antitussive activity of noscapine. Noscapine, and its synthetic derivatives called noscapinoids, are known to interact with microtubules and inhibit cancer cell proliferation.
MedKoo Cat#: 578275
Name: Noscapine camphorsulfonate
CAS#: 25333-79-3 (camphorsulfonate)
Chemical Formula: C32H39NO11S
Exact Mass: 645.2244
Molecular Weight: 645.72
Elemental Analysis: C, 59.52; H, 6.09; N, 2.17; O, 27.25; S, 4.97
The following data is based on the product molecular weight 645.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
