Noscapine is an opioid alkaloid derived from the opium poppy (Papaver somniferum). It is a non-addictive antitussive (cough suppressant) used to treat persistent, non-productive cough. Noscapine's antitussive effects appear to be primarily mediated by its σ–receptor agonist activity. Evidence for this mechanism is suggested by experimental evidence in rats. Pretreatment with rimcazole, a σ-specific antagonist, causes a dose-dependent reduction in antitussive activity of noscapine. Noscapine, and its synthetic derivatives called noscapinoids, are known to interact with microtubules and inhibit cancer cell proliferation.
MedKoo Cat#: 414492
Name: Noscapine embonate
CAS#: 106611-48-7 (embonate)
Chemical Formula: C45H39NO13
Exact Mass: 801.2421
Molecular Weight: 801.80
Elemental Analysis: C, 67.41; H, 4.90; N, 1.75; O, 25.94
The following data is based on the product molecular weight 801.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
