Opiranserin (also known as VVZ-149) is a dual-acting analgesic with selective antagonism at glycine transporter type 2 (GlyT2) and serotonin 5-HT2A receptors. It was primarily developed for postoperative pain management. In preclinical models, Opiranserin showed potent antinociceptive effects, with GlyT2 inhibition enhancing glycine-mediated inhibitory neurotransmission in the spinal cord, and 5-HT2A antagonism modulating central pain perception.
MedKoo Cat#: 414595
Name: Opiranserin HCl
CAS#: 1440796-75-7 (HCl)
Chemical Formula: C21H35ClN2O5
Exact Mass: 0.0000
Molecular Weight: 430.97
Elemental Analysis: C, 58.53; H, 8.19; Cl, 8.23; N, 6.50; O, 18.56
The following data is based on the product molecular weight 430.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
