Opiranserin (also known as VVZ-149) is a dual-acting analgesic with selective antagonism at glycine transporter type 2 (GlyT2) and serotonin 5-HT2A receptors. It was primarily developed for postoperative pain management. In preclinical models, Opiranserin showed potent antinociceptive effects, with GlyT2 inhibition enhancing glycine-mediated inhibitory neurotransmission in the spinal cord, and 5-HT2A antagonism modulating central pain perception.
MedKoo Cat#: 561123
Name: Opiranserin free base
CAS#: 1441000-45-8 (free base)
Chemical Formula: C21H34N2O5
Exact Mass: 394.2468
Molecular Weight: 394.51
Elemental Analysis: C, 63.93; H, 8.69; N, 7.10; O, 20.28
The following data is based on the product molecular weight 394.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
