Synonym
Homochlorcyclizine; NSC25132; NSC-25132; NSC 25132
IUPAC/Chemical Name
1-(p-Chloro-alpha-phenylbenzyl)hexahydro-4-methyl-1H-1,4-diazepine
InChi Key
WEUCDJCFJHYFRL-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23ClN2/c1-21-12-5-13-22(15-14-21)19(16-6-3-2-4-7-16)17-8-10-18(20)11-9-17/h2-4,6-11,19H,5,12-15H2,1H3
SMILES Code
CN1CCN(C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3)CCC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
314.86
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: FISHERMAN EW, FEINBERG SM, FEINBERG AR, PRUZANSKY JJ. Homochlorcyclizine: an antiallergic drug with multiple clinical properties. J Allergy. 1960 May- Jun;31:232-6. doi: 10.1016/0021-8707(60)90051-4. PMID: 13823261.
2: Chang TS, Chen CT. Inhibitory effect of homochlorcyclizine on melanogenesis in α-melanocyte stimulating hormone-stimulated mouse B16 melanoma cells. Arch Pharm Res. 2012 Jan;35(1):119-27. doi: 10.1007/s12272-012-0113-z. Epub 2012 Feb 2. PMID: 22297750.
3: Suzuki A, Yasui-Furukori N, Mihara K, Kondo T, Furukori H, Inoue Y, Kaneko S, Otani K. Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. Ther Drug Monit. 2003 Apr;25(2):192-6. doi: 10.1097/00007691-200304000-00008. PMID: 12657913.
4: Nishikata M, Nakai A, Fushida H, Miyake K, Arita T, Iseki K, Miyazaki K. Enantioselective pharmacokinetics of homochlorcyclizine: disposition of (+)- and (-)-homochlorcyclizine after intravenous and oral administration of racemic homochlorcyclizine to rats. J Pharm Pharmacol. 1994 Jul;46(7):591-5. doi: 10.1111/j.2042-7158.1994.tb03863.x. PMID: 7996389.
5: Miyazawa T. [Experimental allergic contact dermatitis and homochlorcyclizine]. Clin Pediatr (Phila). 1968 Sep;7(9):302-3. Japanese. PMID: 4386436.
6: Nishikata M, Nakai A, Fushida H, Miyake K, Arita T, Iseki K, Miyazaki K, Nomura A. Enantioselective pharmacokinetics of homochlorcyclizine. III. Simultaneous determination of (+)- and (-)- homochlorcyclizine in human urine by high-performance liquid chromatography. J Chromatogr. 1993 Feb 26;612(2):239-44. PMID: 8096848.
7: Taniguchi K, Masuda Y, Takanaka K. Inhibitory effects of histamine H1 receptor blocking drugs on metabolic activations of neutrophils. J Pharmacobiodyn. 1991 Feb;14(2):87-93. doi: 10.1248/bpb1978.14.87. PMID: 1678430.
8: Oishi R, Shishido S, Yamori M, Saeki K. Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain. Naunyn Schmiedebergs Arch Pharmacol. 1994 Feb;349(2):140-4. doi: 10.1007/BF00169830. PMID: 7513381.
9: Nishikata M, Nomura A, Iseki K, Miyazaki K, Nakai A, Fushida H, Miyake K, Arita T. Enantioselective pharmacokinetics of homochlorcyclizine. II: Disposition and metabolism of (+)-, (-)- and racemic homochlorcyclizine after oral administration to man. Eur J Clin Pharmacol. 1992;43(5):533-8. doi: 10.1007/BF02285097. PMID: 1362384.
10: GIRARD JP. [Clinical trials with a new anti-allergic agent, homochlorcyclizine. Effects on urinary elimination of the metabolite of serotonin]. Ther Umsch. 1962 Feb;19:50-3. French. PMID: 13898853.
