Nepinalone HCl is the salt form of Nepinalone Free Base, a new alchilaminate derivative of β-tetralone, which possess a non-opioid antitussive activity. Nepinalone racemus exerted a significant antitussive activity and both L- and D-isomers confirmed to possess a significant dose-correlated antitussive effect with better trend of activity for D-isomer, but not statistically significant. It was predicted to act via sigma receptors. Occasionally, episodes of gastric intolerance have been reported and rapidly receded when treatment was stopped. The use of doses higher than those recommended could cause drowsiness.
MedKoo Cat#: 414328
Name: Nepinalone HCl
CAS#: 22443-55-6 (HCl)
Chemical Formula: C18H26ClNO
Exact Mass: 307.1703
Molecular Weight: 307.86
Elemental Analysis: C, 70.23; H, 8.51; Cl, 11.51; N, 4.55; O, 5.20
The following data is based on the product molecular weight 307.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
