Synonym
SB-706375; SB 706375; SB706375.
IUPAC/Chemical Name
2-bromo-4,5-dimethoxy-N-[3-[(3R)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)phenyl]benzenesulfonamide
InChi Key
BPOWQJYAMDEAFF-CYBMUJFWSA-N
InChi Code
InChI=1S/C20H22BrF3N2O5S/c1-26-7-6-13(11-26)31-16-8-12(4-5-14(16)20(22,23)24)25-32(27,28)19-10-18(30-3)17(29-2)9-15(19)21/h4-5,8-10,13,25H,6-7,11H2,1-3H3/t13-/m1/s1
SMILES Code
O=S(C1=CC(OC)=C(OC)C=C1Br)(NC2=CC=C(C(F)(F)F)C(O[C@H]3CN(C)CC3)=C2)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
539.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Forty EJ, Ashton N. The urotensin system is up-regulated in the pre-hypertensive spontaneously hypertensive rat. PLoS One. 2013 Dec 5;8(12):e83317. doi: 10.1371/journal.pone.0083317. eCollection 2013. PubMed PMID: 24340095; PubMed Central PMCID: PMC3855556.
2: Forty EJ, Ashton N. Ontogeny of the renal urotensin II system in the rat. Exp Physiol. 2012 Jun;97(6):785-95. doi: 10.1113/expphysiol.2011.063172. Epub 2012 Feb 10. PubMed PMID: 22327329.
3: Cosenzi A. Non peptidic urotensin II antagonists: perspectives for a new class of drugs. Cardiovasc Hematol Agents Med Chem. 2008 Apr;6(2):80-91. Review. PubMed PMID: 18473773.
4: Douglas SA, Behm DJ, Aiyar NV, Naselsky D, Disa J, Brooks DP, Ohlstein EH, Gleason JG, Sarau HM, Foley JJ, Buckley PT, Schmidt DB, Wixted WE, Widdowson K, Riley G, Jin J, Gallagher TF, Schmidt SJ, Ridgers L, Christmann LT, Keenan RM, Knight SD, Dhanak D. Nonpeptidic urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375. Br J Pharmacol. 2005 Jul;145(5):620-35. PubMed PMID: 15852036; PubMed Central PMCID: PMC1576177.
