MedKoo Cat#: 562954 | Name: BGT1-IN-9

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BGT1-IN-9 is the first small-molecule substrate identified with high selectivity for BGT1 over the three other GAT subtypes. It also acts as a M1 muscarinic agonist.

Chemical Structure

BGT1-IN-9
BGT1-IN-9
CAS#185444-92-2

Theoretical Analysis

MedKoo Cat#: 562954

Name: BGT1-IN-9

CAS#: 185444-92-2

Chemical Formula: C5H10ClN3O2

Exact Mass: 179.0462

Molecular Weight: 179.60

Elemental Analysis: C, 33.44; H, 5.61; Cl, 19.74; N, 23.40; O, 17.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
BGT1-IN-9; BGT1 IN 9; BGT1IN9; BGT1-inhibitor-9; BGT1 inhibitor 9;
IUPAC/Chemical Name
2-Amino-1,4,5,6-tetrahydro-5-pyrimidinecarboxylic acid hydrochloride
InChi Key
QXGIRCVGFLZIDS-UHFFFAOYSA-N
InChi Code
InChI=1S/C5H9N3O2.ClH/c6-5-7-1-3(2-8-5)4(9)10;/h3H,1-2H2,(H,9,10)(H3,6,7,8);1H
SMILES Code
O=C(C1CN=C(N)NC1)O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 179.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Al-Khawaja A, Haugaard AS, Marek A, Löffler R, Thiesen L, Santiveri M, Damgaard M, Bundgaard C, Frølund B, Wellendorph P. Pharmacological Characterization of [(3)H]ATPCA as a Substrate for Studying the Functional Role of the Betaine/GABA Transporter 1 and the Creatine Transporter. ACS Chem Neurosci. 2018 Mar 21;9(3):545-554. doi: 10.1021/acschemneuro.7b00351. Epub 2017 Nov 22. PubMed PMID: 29131576. 2: Al-Khawaja A, Petersen JG, Damgaard M, Jensen MH, Vogensen SB, Lie ME, Kragholm B, Bräuner-Osborne H, Clausen RP, Frølund B, Wellendorph P. Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1). Neurochem Res. 2014 Oct;39(10):1988-96. doi: 10.1007/s11064-014-1336-9. Epub 2014 May 23. PubMed PMID: 24852577. 3: Suñol C, Babot Z, Cristòfol R, Sonnewald U, Waagepetersen HS, Schousboe A. A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures. Neurochem Res. 2010 Sep;35(9):1384-90. doi: 10.1007/s11064-010-0196-1. Epub 2010 May 30. PubMed PMID: 20512624. 4: Moeckel GW, Zhang L, Fogo AB, Hao CM, Pozzi A, Breyer MD. COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. J Biol Chem. 2003 May 23;278(21):19352-7. Epub 2003 Mar 9. PubMed PMID: 12637551.