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MedKoo Cat#: 112153 | Name: Perphenazine Sulfoxide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Perphenazine sulfoxide is an active metabolite of the typical antipsychotic perphenazine.

Chemical Structure

Perphenazine Sulfoxide
CAS#10078-25-8

Theoretical Analysis

MedKoo Cat#: 112153

Name: Perphenazine Sulfoxide

CAS#: 10078-25-8

Chemical Formula: C21H26ClN3O2S

Exact Mass: 419.1434

Molecular Weight: 419.97

Elemental Analysis: C, 60.06; H, 6.24; Cl, 8.44; N, 10.01; O, 7.62; S, 7.63

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 610.00 2 Weeks
25mg USD 915.00 2 Weeks
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Related CAS #
No Data
Synonym
Perphenazine Sulfoxide
IUPAC/Chemical Name
2-chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)-10H-phenothiazine 5-oxide
InChi Key
WXJXTMQMAOYROI-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H26ClN3O2S/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)28(21)27)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
SMILES Code
O=S1C2=C(C=CC=C2)N(C3=CC(Cl)=CC=C31)CCCN4CCN(CCO)CC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
DMF 3.0 7.14
DMSO 2.0 4.76
Ethanol 3.0 7.14
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 419.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li X, Blondino FE, Hindle M, Soine WH, Byron PR. Stability and characterization of perphenazine aerosols generated using the capillary aerosol generator. Int J Pharm. 2005 Oct 13;303(1-2):113-24. doi: 10.1016/j.ijpharm.2005.07.010. PMID: 16139453. 2: Foglia JP, Sorisio D, Kirshner MA, Mulsant BH, Perel JM. Quantitative determination of perphenazine and its metabolites in plasma by high-performance liquid chromatography and coulometric detection. J Chromatogr B Biomed Appl. 1995 Jun 23;668(2):291-7. doi: 10.1016/0378-4347(95)00074-s. PMID: 7581864. 3: Beaulieu N, Lovering EG. Liquid chromatographic method for perphenazine and its sulfoxide in pharmaceutical dosage forms for determination of stability. J Assoc Off Anal Chem. 1986 Jan-Feb;69(1):167-9. PMID: 3949688. 4: HOTOVY R, KAPFF-WALTER J. [The pharmacological properties of perphenazine sulfoxide]. Arzneimittelforschung. 1960 Aug;10:638-50. German. PMID: 13716113. 5: HOTOVY R, KAPFF-WALTER J. [On the pharmacology of perphenazine sulfoxide]. Med Esp. 1960;2:205-8. German. PMID: 14403323.