MedKoo Cat#: 150113 | Name: Torbafylline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Torbafylline is a xanthine derivative. Torbafylline significantly reduces the degree of capillary endothelial cell swelling. Torbafylline treatment causes an increased lactate dehydrogenase activity in intact fast muscles and decreases it in soleus.

Chemical Structure

Torbafylline
CAS#105102-21-4

Theoretical Analysis

MedKoo Cat#: 150113

Name: Torbafylline

CAS#: 105102-21-4

Chemical Formula: C16H26N4O4

Exact Mass: 338.1950

Molecular Weight: 338.41

Elemental Analysis: C, 56.79; H, 7.74; N, 16.56; O, 18.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Torbafylline; Torbafylline [INN];
IUPAC/Chemical Name
7-(ethoxymethyl)-1-(5-hydroxy-5-methylhexyl)-3-methylpurine-2,6-dione
InChi Key
QSXXLDDWVCEBFP-UHFFFAOYSA-N
InChi Code
1S/C16H26N4O4/c1-5-24-11-19-10-17-13-12(19)14(21)20(15(22)18(13)4)9-7-6-8-16(2,3)23/h10,23H,5-9,11H2,1-4H3
SMILES Code
O=C(N1CCCCC(C)(O)C)N(C)C2=C(N(COCC)C=N2)C1=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 338.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Combaret L, Tilignac T, Claustre A, Voisin L, Taillandier D, Obled C, Tanaka K, Attaix D. Torbafylline (HWA 448) inhibits enhanced skeletal muscle ubiquitin- proteasome-dependent proteolysis in cancer and septic rats. Biochem J. 2002 Jan 15;361(Pt 2):185-92. doi: 10.1042/0264-6021:3610185. PMID: 11772390; PMCID: PMC1222298. 2: Hudlicka O, Egginton S, Brown MD, Okyayuz-Baklouti I. Effect of torbafylline on muscle blood flow, performance, and capillary supply in ischemic muscles subjected to varying levels of activity. Can J Physiol Pharmacol. 1994 Jul;72(7):811-7. doi: 10.1139/y94-115. PMID: 7828090.