Synonym
Butriptyline Free Base; AY2014; AY-2014; AY 2014; Evadyne
IUPAC/Chemical Name
N,N,2-trimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)propan-1-amine
InChi Key
ALELTFCQZDXAMQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H27N/c1-16(15-22(2)3)14-21-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)21/h4-11,16,21H,12-15H2,1-3H3
SMILES Code
CC(CC1C2=CC=CC=C2CCC3=CC=CC=C13)CN(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
293.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Gonzalez R, Kraml M. Butriptyline: improved gas-liquid chromatographic method using a nitrogen-phosphorus detector for its determination in serum. Clin Biochem. 1980 Aug;13(4):141-3. doi: 10.1016/s0009-9120(80)90988-1. PMID: 6893814.
2: Remakus BL, Kessel LJ, Trichtinger MD, Montgomery P, Griffiths JP. Butriptyline (Evadyne) and the Mexican connection. N Engl J Med. 1981 Jun 18;304(25):1543-4. doi: 10.1056/NEJM198106183042512. PMID: 6894482.
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4: Voith K, Herr F. Psychopharmacological evaluation of a new antidepressant: butriptyline. Arch Int Pharmacodyn Ther. 1969 Dec;182(2):318-31. PMID: 5371184.
5: Burrows GD, Norman TR, Maguire KP, Rubinstein G, Scoggins BA, Davies B. A new antidepressant butriptyline: plasma levels and clinical response. Med J Aust. 1977 Oct 29;2(18):604-6. doi: 10.5694/j.1326-5377.1977.tb107663.x. PMID: 579645.
6: Poch GF. Butriptyline in the treatment of depression. J Med. 1971;2(5):340-3. PMID: 5292013.
7: Di Carlo R, Pagnini G, Pelagalli GV. Effect of amitriptyline and butriptyline on fetal development in rats. J Med. 1971;2(5):271-5. PMID: 5292012.
8: Bourgouin J, Gagnon MA, Elie R, Dvornik D, Gonzalez R, Kraml M. Butriptyline: human pharmacokinetics and comparative bioavailability of conventional and sustained release formulations. Biopharm Drug Dispos. 1981 Apr-Jun;2(2):123-30. doi: 10.1002/bdd.2510020204. PMID: 6894708.
9: Kapadia AP, Smith SM. A multi-centre general practitioner assessment of butriptyline hydrochloride ('Evadyne'). Curr Med Res Opin. 1976;4(4):278-84. doi: 10.1185/03007997609109318. PMID: 1036481.
10: Herr F, Voith K, Jaramillo J. The pharmacology of butriptyline. J Med. 1971;2(5):258-70. PMID: 5292011.
11: Hallstrom C, Brooks N. ECG changes on butriptyline. Commun Psychopharmacol. 1979;3(1):55-8. PMID: 380886.
12: Grivois H. Butriptyline. A new antidepressant compound. J Med. 1971;2(5):276-89. PMID: 4948361.
13: Two more new antidepressives: mianserin and butriptyline. Drug Ther Bull. 1977 Jan 7;15(1):1-2. PMID: 576211.
14: González M, Montaño H. Clinical experience with butriptyline (AY-62014) in the treatment of depressions. J Med. 1971;2(5):296-9. PMID: 4948364.
15: Villanueva Galván R, Krasovsky Zozula J. Enurésis y trastornos de conducta en niños. Tratamiento con butriptilina como única medida terapéutica [Enuresis and behavior disorders in children. Treatment with butriptyline as the only therapeutic treatment]. Prensa Med Mex. 1976 Nov-Dec;41(11-12):417-27. Spanish. PMID: 1037453.
16: Pérez de Francisco C, Castilla J, Nieto Gómez D. La butriptilina en 60 pacientes deprimidos [Butriptyline in 60 depressed patients]. Prensa Med Mex. 1973 Jul-Aug;38(7):290-2. Spanish. PMID: 4789186.
17: Garcia JA. Clinical trials with butriptyline. J Med. 1971;2(5):290-2. PMID: 4948362.
18: Marks IN. Healing of peptic ulcers on conventional antacid therapy with or without butriptyline. S Afr Med J. 1979 Mar 3;55(9):331-4. PMID: 375436.
19: Brodie NH, McGhie RL, O'Hara J, O'Hara H, Valle-Jones JC, Smith SM. Butriptyline in the treatment of depression. A multicentre general-practice trial. Practitioner. 1978 Jul;221(1321):128-30. PMID: 366590.
20: Jaramillo J, Greenberg R. Comparative pharmacological studies on butriptyline and some related standard tricyclic antidepressants. Can J Physiol Pharmacol. 1975 Feb;53(1):104-12. doi: 10.1139/y75-014. PMID: 166748.
