Synonym
Butriptyline hydrochloride; Butriptyline HCl
IUPAC/Chemical Name
3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)-N,N,2-trimethylpropan-1-amine hydrochloride
InChi Key
MCWAFEJHLHEFOD-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H27N.ClH/c1-16(15-22(2)3)14-21-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)21;/h4-11,16,21H,12-15H2,1-3H3;1H
SMILES Code
CC(CC1C2=CC=CC=C2CCC3=CC=CC=C13)CN(C)C.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
329.91
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hutchison JD Jr, Harris A, Rasmussen SA, Schlueter SA. Concentrations of butriptyline in biological fluids following a fatal overdose. J Anal Toxicol. 1994 Jul-Aug;18(4):220-4. PubMed PMID: 7967544.
2: Ohi M, Kanno E, Yamada S, Yoshikawa T, Ui H, Watanuki K. [Clinical results of Evadyne (zinc oxide-eugenol-guaiacol cement) applied to indirect pulp capping]. Tohoku Shika Daigaku Gakkai Shi. 1988 Mar;15(1):25-30. Japanese. PubMed PMID: 3255643.
3: Dulloo AG, Miller DS. Screening of drugs for thermogenic anti-obesity properties: antidepressants. Ann Nutr Metab. 1987;31(2):69-80. PubMed PMID: 3592617.
4: Atherton AD, Barry BW. Photon correlation spectroscopy of surface active cationic drugs. J Pharm Pharmacol. 1985 Dec;37(12):854-62. PubMed PMID: 2868091.
5: Richelson E, Pfenning M. Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: most antidepressants selectively block norepinephrine uptake. Eur J Pharmacol. 1984 Sep 17;104(3-4):277-86. PubMed PMID: 6499924.
6: Bonnet JJ, Lemasson MH, Costentin J. Simultaneous evaluation by a double labelling method of drug-induced uptake inhibition and release of dopamine in synaptosomal preparation of rat striatum. Biochem Pharmacol. 1984 Jul 1;33(13):2129-35. PubMed PMID: 6743357.
7: Kopanski C, Türck M, Schultz JE. Effects of long-term treatment of rats with antidepressants on adrenergic-receptor sensitivity in cerebral cortex: Structure activity study. Neurochem Int. 1983;5(5):649-59. PubMed PMID: 20487994.
8: Guelfi JD, Dreyfus JF, Delcros M, Pichot P. A double-blind controlled multicenter trial comparing butriptyline with amitriptyline. Neuropsychobiology. 1983;9(2-3):142-6. PubMed PMID: 6353270.
9: Fiumara RS, Caporali M, Zanasi M, Parisi LL. [Therapeutic profile of butriptyline in ambulatory psychiatric practice. Preliminary data]. Clin Ter. 1982 Jan 31;100(2):153-6. Italian. PubMed PMID: 6897901.
10: Crawley JN. Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines. Pharmacol Biochem Behav. 1981 Nov;15(5):695-9. PubMed PMID: 6118883.
11: Desiles M, Rips R. Use of potentiation of thyrotrophin releasing hormone (TRH)-induced hyperthermia as a test for screening antidepressants which activate alpha-adrenoceptor systems. Br J Pharmacol. 1981 Sep;74(1):81-6. PubMed PMID: 6115696; PubMed Central PMCID: PMC2071883.
12: Remakus BL, Kessel LJ, Trichtinger MD, Montgomery P, Griffiths JP. Butriptyline (Evadyne) and the Mexican connection. N Engl J Med. 1981 Jun 18;304(25):1543-4. PubMed PMID: 6894482.
13: Bourgouin J, Gagnon MA, Elie R, Dvornik D, Gonzalez R, Kraml M. Butriptyline: human pharmacokinetics and comparative bioavailability of conventional and sustained release formulations. Biopharm Drug Dispos. 1981 Apr-Jun;2(2):123-30. PubMed PMID: 6894708.
14: Shaw SH. Management of depressive neurosis. Practitioner. 1981 Feb;225(1352):228-30. PubMed PMID: 7022427.
15: Pugsley TA, Lippmann W. Affinity of butriptyline and other tricyclic antidepressants for alpha-adrenoceptor binding sites in rat brain. J Pharm Pharmacol. 1981 Feb;33(2):113-5. PubMed PMID: 6111592.
16: Gonzalez R, Kraml M. Butriptyline: improved gas-liquid chromatographic method using a nitrogen-phosphorus detector for its determination in serum. Clin Biochem. 1980 Aug;13(4):141-3. PubMed PMID: 6893814.
17: Amsterdam J, Brunswick D, Mendels J. The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels. Am J Psychiatry. 1980 Jun;137(6):653-62. Review. PubMed PMID: 6990798.
18: Boyer P, Tsamis M, Mahuzier P. [Pharmacokinetics and plasma concentration of polycyclic antidepressants. General review of the product]. Encephale. 1980;6(4):333-47. Review. French. PubMed PMID: 6108206.
19: Pugsley TA, Lippmann W. Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities. Naunyn Schmiedebergs Arch Pharmacol. 1979 Sep;308(3):239-47. PubMed PMID: 503251.
20: Norman TR, Burrows GD, Davies BM, Wurm JM. Determination of viloxazine in plasma by GLC. Br J Clin Pharmacol. 1979 Aug;8(2):169-71. PubMed PMID: 486292; PubMed Central PMCID: PMC1429776.
