ICI-63197 | CAS# 27277-00-5 | PDE4 inhibitor

MedKoo Cat#: 574744 | Name: ICI-63197

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI-63197 is a phosphodiesterase (PDE) 4 inhibitor and antidepressant.

Chemical Structure

ICI-63197

CAS#27277-00-5

Theoretical Analysis

MedKoo Cat#: 574744

Name: ICI-63197

CAS#: 27277-00-5

Chemical Formula: C9H13N5O

Exact Mass: 207.1120

Molecular Weight: 207.24

Elemental Analysis: C, 52.16; H, 6.32; N, 33.79; O, 7.72

Price and Availability

Size	Price	Availability
500mg	USD 250.00	2 Weeks
1g	USD 450.00	2 Weeks
5g	USD 1,250.00	2 Weeks

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Related CAS #

No Data

Synonym

ICI 63197; ICI-63197; ICI63197

IUPAC/Chemical Name

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one

InChi Key

UQDVRVNMIJAGRK-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12)

SMILES Code

O=C1N(CCC)C2=NC(N)=NN2C=C1C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Potent phosphodiesterase (PDE) 4 inhibitor (IC50 = 35 nM for inhibition of [3H]-rolipram binding to rat brain).

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	10.0	48.25
	DMSO	10.0	48.25
	PBS (pH 7.2)	0.2	0.97

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 207.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1. Kaulen et al (1989) Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram. Brain Res. 503 229 PMID: 2557965 2. Wachtel (1983) Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology 22 267 PMID: 6302550 3. Zhao et al (2003) Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram J.Pharmacol.Exp.Ther. 305 565 PMID: 12704225