KST012174 HCl | CAS#1392224-35-9

MedKoo Cat#: 407962 | Name: KST012174 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KST012174 is a HIF-1α inhibitor. KST012174 involves in the HIF-1α/p300 protein−protein interaction.

Chemical Structure

KST012174 HCl

CAS#1392224-35-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 407962

Name: KST012174 HCl

CAS#: 1392224-35-9 (HCl)

Chemical Formula: C27H34Cl2N6O2

Exact Mass:

Molecular Weight: 545.51

Elemental Analysis: C, 59.45; H, 6.28; Cl, 13.00; N, 15.41; O, 5.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1392224-35-9 (HCl) 1392266-84-0 (free base)

Synonym

KST012174; KST-012174; KST 012174; KST012174 HCl,

IUPAC/Chemical Name

4-(2-((2-chlorophenyl)amino)-2-oxoethyl)-N-((5-isobutyl-1-phenyl-1H-pyrazol-3-yl)methyl)piperazine-1-carboxamide hydrochloride

InChi Key

XHHMTZMVSPEWCP-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H33ClN6O2.ClH/c1-20(2)16-23-17-21(31-34(23)22-8-4-3-5-9-22)18-29-27(36)33-14-12-32(13-15-33)19-26(35)30-25-11-7-6-10-24(25)28;/h3-11,17,20H,12-16,18-19H2,1-2H3,(H,29,36)(H,30,35);1H

SMILES Code

O=C(N1CCN(CC(NC2=CC=CC=C2Cl)=O)CC1)NCC3=NN(C4=CC=CC=C4)C(CC(C)C)=C3.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Stabilization of a key regulator termed the hypoxia inducible factor (HIF)-1α under oxygen deficient environment around tumor is known to elicit expression of VEGF through binding to p300. Thus, inhibition of the HIF-1α–p300 interaction would lead to down-regulation of VEGF expression, thereby providing potential cancer therapeutics.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 545.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kwon HS, Kim DR, Yang EG, Park YK, Ahn HC, Min SJ, Ahn DR. Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1α-p300 interaction by a small molecule. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5249-52. doi: 10.1016/j.bmcl.2012.06.054. Epub 2012 Jun 23. PubMed PMID: 22789427.