Synonym
Diminazene Free Base
IUPAC/Chemical Name
Benzenecarboximidamide, 4,4'-(1-triazene-1,3-diyl)bis-
InChi Key
XNYZHCFCZNMTFY-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)
SMILES Code
N=C(C1=CC=C(/N=N/NC2=CC=C(C(N)=N)C=C2)C=C1)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
281.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: da Silva Oliveira GL, de Freitas RM. Diminazene aceturate--An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics. Pharmacol Res. 2015 Dec;102:138-57. doi: 10.1016/j.phrs.2015.10.005. Epub 2015 Oct 22. PMID: 26470648.
2: Peregrine AS, Mamman M. Pharmacology of diminazene: a review. Acta Trop. 1993 Sep;54(3-4):185-203. doi: 10.1016/0001-706x(93)90092-p. PMID: 7902657.
3: Kuriakose S, Uzonna JE. Diminazene aceturate (Berenil), a new use for an old compound? Int Immunopharmacol. 2014 Aug;21(2):342-5. doi: 10.1016/j.intimp.2014.05.027. Epub 2014 Jun 2. PMID: 24893117.
4: Nixon SA, Saez NJ, Herzig V, King GF, Kotze AC. The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro. Vet Parasitol. 2019 Jun;270:40-46. doi: 10.1016/j.vetpar.2019.05.008. Epub 2019 May 19. PMID: 31213240.
5: Silva de Almeida TC, Lanza K, da Silva Filha R, C Campos LMC, Fonseca EG, Chagas MW, Rocha NP, de Sá MA, Vieira MAR, Caliari MV, Kangussu LM, Ferreira AJ, Simões E Silva AC. ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats. Clin Sci (Lond). 2020 Dec 11;134(23):3093-3106. doi: 10.1042/CS20201022. PMID: 33206153.
6: Tuvshintulga B, Sivakumar T, Yokoyama N, Igarashi I. Development of unstable resistance to diminazene aceturate in Babesia bovis. Int J Parasitol Drugs Drug Resist. 2019 Apr;9:87-92. doi: 10.1016/j.ijpddr.2019.02.001. Epub 2019 Feb 13. PMID: 30785049; PMCID: PMC6382846.
7: Odeniran PO, Macleod ET, Ademola IO, Welburn SC. Suspected resistance of Trypanosoma species to diminazene aceturate on a cattle farm in Nigeria. Trop Anim Health Prod. 2019 Sep;51(7):2091-2094. doi: 10.1007/s11250-019-01902-5. Epub 2019 Apr 17. PMID: 30997632.
8: Badae NM, El Naggar AS, El Sayed SM. Is the cardioprotective effect of the ACE2 activator diminazene aceturate more potent than the ACE inhibitor enalapril on acute myocardial infarction in rats? Can J Physiol Pharmacol. 2019 Jul;97(7):638-646. doi: 10.1139/cjpp-2019-0078. Epub 2019 Mar 6. PMID: 30840489.
9: Castardeli C, Sartório CL, Pimentel EB, Forechi L, Mill JG. The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats. Biomed Pharmacother. 2018 Nov;107:212-218. doi: 10.1016/j.biopha.2018.07.170. Epub 2018 Aug 6. PMID: 30092400.
10: Velkoska E, Patel SK, Burrell LM. Angiotensin converting enzyme 2 and diminazene: role in cardiovascular and blood pressure regulation. Curr Opin Nephrol Hypertens. 2016 Sep;25(5):384-95. doi: 10.1097/MNH.0000000000000254. PMID: 27367913.
