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MedKoo Cat#: 525280 | Name: Diminazene diaceturate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diminazene diaceturate is a potent inhibitor of mesotrypsin, anti-infective against certain protozoa such as Babesia, Trypanosoma and Cytauxzoon.

Chemical Structure

Diminazene diaceturate
CAS#908-54-3 (diaceturate)

Theoretical Analysis

MedKoo Cat#: 525280

Name: Diminazene diaceturate

CAS#: 908-54-3 (diaceturate)

Chemical Formula: C22H29N9O6

Exact Mass: 515.2241

Molecular Weight: 515.53

Elemental Analysis: C, 51.26; H, 5.67; N, 24.45; O, 18.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
536-71-0 (free base) 908-54-3 (diaceturate) 15114-96-2 (monoaceturate) 31384-83-5 (2HCl)
Synonym
Diminazene diaceturate
IUPAC/Chemical Name
4-[2-(4-carbamimidoylphenyl)iminohydrazinyl]benzene-carboximidamide Diaceturate
InChi Key
OKQSSSVVBOUMNZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H15N7.2C4H7NO3/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18;2*1-3(6)5-2-4(7)8/h1-8H,(H3,15,16)(H3,17,18)(H,19,20);2*2H2,1H3,(H,5,6)(H,7,8)
SMILES Code
N=C(C1=CC=C(N/N=N/C2=CC=C(C(N)=N)C=C2)C=C1)N.O=C(C)NCC(O)=O.O=C(C)NCC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 515.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Exp Parasitol. 2017 May;176:59-65. doi: 10.1016/j.exppara.2017.03.002. Epub 2017 Mar 9. PubMed PMID: 28286324. 4: Akode RM, Wagiealla Shantier S, Ahmed Gadkariem E, Awadalla Mohamed M. Simultaneous Determination and Stability Studies on Diminazene Diaceturate and Phenazone Using Developed Derivative Spectrophotometric Method. Int J Anal Chem. 2017;2017:4269587. doi: 10.1155/2017/4269587. Epub 2017 Jan 26. PubMed PMID: 28246529; PubMed Central PMCID: PMC5299212. 5: Cossic BG, Adjahoutonon B, Gloaguen P, Dibanganga GL, Maganga G, Leroy P, MacLeod ET, Picozzi K. Trypanosomiasis challenge estimation using the diminazene aceturate (Berenil) index in Zebu in Gabon. Trop Anim Health Prod. 2017 Mar;49(3):619-624. doi: 10.1007/s11250-017-1239-2. Epub 2017 Feb 14. PubMed PMID: 28194625; PubMed Central PMCID: PMC5323502. 6: Gillingwater K, Kunz C, Braghiroli C, Boykin DW, Tidwell RR, Brun R. In Vitro, Ex Vivo, and In Vivo Activities of Diamidines against Trypanosoma congolense and Trypanosoma vivax. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02356-16. doi: 10.1128/AAC.02356-16. Print 2017 May. PubMed PMID: 28193658; PubMed Central PMCID: PMC5404523. 7: Waema MW, Maina NW, Ngotho M, Karanja SM, Gachie BM, Maranga DN, Kagira JM. IgM, lgG and IL-6 profiles in the Trypanosoma brucei brucei monkey model of human African trypanosomiasis. Acta Trop. 2017 Apr;168:45-49. doi: 10.1016/j.actatropica.2017.01.012. Epub 2017 Jan 15. PubMed PMID: 28099874. 8: Bal MS, Mahajan V, Filia G, Kaur P, Singh A. Diagnosis and management of bovine babesiosis outbreaks in cattle in Punjab state. Vet World. 2016 Dec;9(12):1370-1374. doi: 10.14202/vetworld.2016.1370-1374. Epub 2016 Dec 6. PubMed PMID: 28096607; PubMed Central PMCID: PMC5234049. 9: Gonde S, Chhabra S, Uppal SK, Singla LD, Randhawa SS. A unique case of Babesia gibsoni infected dog with paraplegia. J Parasit Dis. 2016 Dec;40(4):1605-1608. Epub 2016 Jan 13. PubMed PMID: 27876993; PubMed Central PMCID: PMC5118365. 10: Maharana BR, Kumar B, Hirani ND. Traditional versus molecular based detection of a rare occurrence of babesiosis in Gir calf and its therapeutic management. J Parasit Dis. 2016 Dec;40(4):1601-1604. Epub 2016 Jan 13. PubMed PMID: 27876992; PubMed Central PMCID: PMC5118364. 11: Ezeh IO, Ugwu EN, Enemuo OV, Obi CF, Iheagwam CN, Ezeokonkwo RC, Onah DN. Efficacy of repeated doses of diminazene aceturate (Dinazene(®)) in the treatment of experimental Trypanosoma brucei infection of Albino rats. Iran J Vet Res. 2016 Spring;17(2):124-129. PubMed PMID: 27822238; PubMed Central PMCID: PMC5090142. 12: Wu SY, Park GY, Kim SH, Hulme J, An SS. Diminazene aceturate: an antibacterial agent for Shiga-toxin-producing Escherichia coli O157:H7. Drug Des Devel Ther. 2016 Oct 14;10:3363-3378. eCollection 2016. PubMed PMID: 27789937; PubMed Central PMCID: PMC5072558. 13: Baldissera MD, Grando TH, de Souza CF, Cossetin LF, da Silva AP, Giongo JL, Monteiro SG. A nanotechnology based new approach for Trypanosoma evansi chemotherapy: In vitro and vivo trypanocidal effect of (-)-α-bisabolol. Exp Parasitol. 2016 Nov;170:156-160. doi: 10.1016/j.exppara.2016.09.018. Epub 2016 Sep 28. PubMed PMID: 27693361. 14: Ademola IO, Odeniran PO. Novel trypanocide from an extract of Pleurotus sajor-caju against Trypanosoma congolense. Pharm Biol. 2017 Dec;55(1):132-138. Epub 2016 Sep 21. PubMed PMID: 27650882. 15: Wang LP, Fan SJ, Li SM, Wang XJ, Gao JL, Yang XH. Protective role of ACE2-Ang-(1-7)-Mas in myocardial fibrosis by downregulating K(Ca)3.1 channel via ERK1/2 pathway. Pflugers Arch. 2016 Nov;468(11-12):2041-2051. Epub 2016 Sep 3. PubMed PMID: 27592222. 16: Velkoska E, Patel SK, Griggs K, Burrell LM. Diminazene Aceturate Improves Cardiac Fibrosis and Diastolic Dysfunction in Rats with Kidney Disease. PLoS One. 2016 Aug 29;11(8):e0161760. doi: 10.1371/journal.pone.0161760. eCollection 2016. PubMed PMID: 27571511; PubMed Central PMCID: PMC5003360. 17: Lopes PR, Moreira MC, Marques SM, Pinto IS, Macedo LM, Silva CC, Freiria-Oliveira AH, Rebelo AC, Reis AA, Rosa DA, Ferreira-Neto ML, Castro CH, Pedrino GR. Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats. Braz J Med Biol Res. 2016 Aug 1;49(9):e5349. doi: 10.1590/1414-431X20165349. PubMed PMID: 27533767; PubMed Central PMCID: PMC4988479. 18: Rizk MA, El-Sayed SA, AbouLaila M, Tuvshintulga B, Yokoyama N, Igarashi I. Large-scale drug screening against Babesia divergens parasite using a fluorescence-based high-throughput screening assay. Vet Parasitol. 2016 Aug 30;227:93-7. doi: 10.1016/j.vetpar.2016.07.032. Epub 2016 Jul 30. PubMed PMID: 27523944. 19: Sudhakara Reddy B, Sivajothi S, Varaprasad Reddy LS, Solmon Raju KG. 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