Synonym
Aminopentamide; Dimevamide; Centrine
IUPAC/Chemical Name
Valeramide, 4-(dimethylamino)-2,2-diphenyl-,
InChi Key
NARHAGIVSFTMIG-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H24N2O/c1-15(21(2)3)14-19(18(20)22,16-10-6-4-7-11-16)17-12-8-5-9-13-17/h4-13,15H,14H2,1-3H3,(H2,20,22)
SMILES Code
CC(CC(C1=CC=CC=C1)(C(N)=O)C2=CC=CC=C2)N(C)C
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
296.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mandal PK, Ren Z, Chen X, Kaluarachchi K, Liao WS, McMurray JS. Structure- Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3). Int J Pept Res Ther. 2013 Mar;19(1):3-12. doi: 10.1007/s10989-012-9313-0. PMID: 24707243; PMCID: PMC3974845.
2: CRONK GA, NAUMANN DE. Some aspects of the pharmacology and clinical application of a parasympatholytic agent, aminopentamide. N Y State J Med. 1956 Sep 1;56(17):2688-91. PMID: 13358891.
3: Serfontein WJ, de Villiers LS. Monitoring aminopentamide urinary excretion by means of multiple 'microphase' extraction - a rapid method for the extraction and concentration of small amounts of lipophilic drugs from large volumes of biological fluids without distillation. S Afr J Med Sci. 1976;41(3):221-8. PMID: 982190.
4: Trisrivirat D, Lawan N, Chenprakhon P, Matsui D, Asano Y, Chaiyen P. Mechanistic insights into the dual activities of the single active site of l-lysine oxidase/monooxygenase from Pseudomonas sp. AIU 813. J Biol Chem. 2020 Aug 7;295(32):11246-11261. doi: 10.1074/jbc.RA120.014055. Epub 2020 Jun 11. PMID: 32527725; PMCID: PMC7415961.
5: LANZETTA A, PASINI C. Sull'azione broncolitica di un nuovo derivato di sintesi: l'aminopentamide [Broncholytic effect of a new synthetic drugs: aminopentamide]. Boll Soc Ital Biol Sper. 1957 Jun;33(6):895-8. Italian. PMID: 13499735.
6: Gal J, Brady JT, Kett J. Gas-chromatographic determination of disopyramide with nitrogen detection. J Anal Toxicol. 1980 Jan-Feb;4(1):15-9. doi: 10.1093/jat/4.1.15. PMID: 6927045.
7: Sato T, Yokota S, Ichihashi R, Miyauchi T, Okubo T, Usui M, Fujii N, Tamura Y. Isolation of Escherichia coli strains with AcrAB-TolC efflux pump-associated intermediate interpretation or resistance to fluoroquinolone, chloramphenicol and aminopenicillin from dogs admitted to a university veterinary hospital. J Vet Med Sci. 2014 Jul;76(7):937-45. doi: 10.1292/jvms.13-0144. Epub 2014 Mar 18. PMID: 24646457; PMCID: PMC4143654.
8: HOEKSTRA JB, TISCH DE, RAKIETEN N, DICKISON HL. The pharmacological activity of DL-alpha, alpha-diphenyl, gamma-dimethylaminovaleramide (centrine). J Pharmacol Exp Ther. 1954 Jan;110(1):55-67. PMID: 13118479.
9: GARCIA-MORATO CASTANO V, JUANES GONZALEZ A. Influencia del centrine sobre las funciones gástricas en el ulcus gástrico duodenal [Effect of centrine on gastric function in gastroduodenal ulcus]. Arch Med Exp. 1955;18(4):419-29. Spanish. PMID: 13373563.
