sEH/AChE Inhibitor 12b | CAS#2490589-09-6 | sEH/AChE Inhibitor

MedKoo Cat#: 150058 | Name: sEH/AChE Inhibitor 12b

Description:

WARNING: This product is for research use only, not for human or veterinary use.

sEH/AChE Inhibitor 12b is a novel dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE Inhibitor 12b is a multitarget profile to provide cumulative effects against neuroinflammation and memory impairment.

Chemical Structure

sEH/AChE Inhibitor 12b

CAS#2490589-09-6

Theoretical Analysis

MedKoo Cat#: 150058

Name: sEH/AChE Inhibitor 12b

CAS#: 2490589-09-6

Chemical Formula: C30H33ClF3N5O3

Exact Mass: 603.2220

Molecular Weight: 604.07

Elemental Analysis: C, 59.65; H, 5.51; Cl, 5.87; F, 9.44; N, 11.59; O, 7.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

sEH/AChE Inhibitor 12b;

IUPAC/Chemical Name

1-(1-(4-((6-Chloro-1,2,3,4-tetrahydroacridin-9-yl)amino)butanoyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

InChi Key

MSNDBGHTMCHRQB-UHFFFAOYSA-N

InChi Code

1S/C30H33ClF3N5O3/c31-19-7-12-24-26(18-19)38-25-5-2-1-4-23(25)28(24)35-15-3-6-27(40)39-16-13-21(14-17-39)37-29(41)36-20-8-10-22(11-9-20)42-30(32,33)34/h7-12,18,21H,1-6,13-17H2,(H,35,38)(H2,36,37,41)

SMILES Code

O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2CCN(C(CCCNC3=C(CCCC4)C4=NC5=CC(Cl)=CC=C53)=O)CC2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 604.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Codony S, Pont C, Griñán-Ferré C, Di Pede-Mattatelli A, Calvó-Tusell C, Feixas F, Osuna S, Jarné-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Pérez B, Bartra C, Sanfeliu C, Juárez-Jiménez J, Morisseau C, Hammock BD, Pallàs M, Vázquez S, Muñoz-Torrero D. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 Mar 24;65(6):4909-4925. doi: 10.1021/acs.jmedchem.1c02150. Epub 2022 Mar 10. PMID: 35271276; PMCID: PMC8958510.