Synonym
Dexpropranolol Free Base; 2R-Propranolol; D-Propranolol; (R)-(+)-propranolol; (+)-Propranolol; R-(+)-Propranolol
IUPAC/Chemical Name
2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (R)- (9CI)
InChi Key
AQHHHDLHHXJYJD-CQSZACIVSA-N
InChi Code
InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/t14-/m1/s1
SMILES Code
O[C@@H](COC1=C2C=CC=CC2=CC=C1)CNC(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
259.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Zhang L, Wu HW, Yuan W, Zheng JW. Propranolol therapy for infantile hemangioma: our experience. Drug Des Devel Ther. 2017 May 8;11:1401-1408. doi: 10.2147/DDDT.S134808. PMID: 28507428; PMCID: PMC5428756.
3: Anderson R, Ramafi G, Theron AJ. Membrane stabilizing, anti-oxidative interactions of propranolol and dexpropranolol with neutrophils. Biochem Pharmacol. 1996 Jul 26;52(2):341-9. doi: 10.1016/0006-2952(96)00212-2. PMID: 8694859.
4: Propranolol. Lancet. 1967 Apr 29;1(7496):939-40. PMID: 4164409.
5: Propranolol. Br Med J. 1966 Nov 26;2(5525):1311-2. PMID: 5924821; PMCID: PMC1944307.
6: Wilson AG, Brooke OG, Lloyd HJ, Robinson BF. Mechanism of action of beta- adrenergic receptor blocking agents in angina pectoris: comparison of action of propranolol with dexpropranolol and practolol. Br Med J. 1969 Nov 15;4(5680):399-401. doi: 10.1136/bmj.4.5680.399. PMID: 4390958; PMCID: PMC1629770.
7: Batra S, Bhushan R. Methods and approaches for determination and enantioseparation of (RS)-propranolol. Biomed Chromatogr. 2019 Jan;33(1):e4370. doi: 10.1002/bmc.4370. Epub 2018 Sep 30. PMID: 30121955.
8: Franchini S, Sorbi C, Linciano P, Brasili L, Tait A. Effect of the rigidification of propranolol, a mixed β-adrenoceptor and 5-HT1AR antagonist. Pharmazie. 2019 Mar 1;74(3):131-135. doi: 10.1691/ph.2019.8878. PMID: 30961676.
9: Rackensperger W, Fritsch W, Schwarz D, Stutte KH, Zerssen D. Wirkung des Beta-Rezeptoren-Blockers Propranolol auf Manien [The effect of the beta- adrenergic blocking agent propranolol in mania (author's transl)]. Arch Psychiatr Nervenkr (1970). 1976 Oct 28;222(2-3):223-43. German. doi: 10.1007/BF02206619. PMID: 999494.
10: Ahlquist RP. Propranolol in hypertension. J Clin Pharmacol. 1977 Feb- Mar;17(2-3):93-4. doi: 10.1002/j.1552-4604.1977.tb04594.x. PMID: 13091.
