Synonym
Dexpropranolol hydrochloride; (R)-Propranolol hydrochloride; Dexpropranolol; Dexpropranolol HCl; AY 20694; AY20694; AY-20694;
IUPAC/Chemical Name
(2R)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol;hydrochloride
InChi Key
ZMRUPTIKESYGQW-PFEQFJNWSA-N
InChi Code
InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m1./s1
SMILES Code
O[C@H](CNC(C)C)COC1=C2C=CC=CC2=CC=C1.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
295.81
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cocker PJ, Lin MY, Tremblay M, Kaur S, Winstanley CA. The β-adrenoceptor blocker propranolol ameliorates compulsive-like gambling behaviour in a rodent slot machine task: implications for iatrogenic gambling disorder. Eur J Neurosci. 2018 Jul 17. doi: 10.1111/ejn.14070. [Epub ahead of print] PubMed PMID: 30019362.
2: Bührer C, Erdeve Ö, Bassler D, Bar-Oz B. Oral propranolol for prevention of threshold retinopathy of prematurity (ROPROP): protocol of a randomised controlled trial. BMJ Open. 2018 Jul 6;8(7):e021749. doi: 10.1136/bmjopen-2018-021749. PubMed PMID: 29982217; PubMed Central PMCID: PMC6042594.
3: Zhu X, Guo X, Liu D, Gong Y, Sun J, Dong C. Promotion of Propranolol Delivery to Hemangiomas by Using Anti-VEGFR Antibody-Conjugated Poly(lactic-co-glycolic acid) Nanoparticles. J Biomed Nanotechnol. 2017 Dec 1;13(12):1694-1705. doi: 10.1166/jbn.2017.2449. PubMed PMID: 29490757.
4: Propranolol Hydrochloride (Hemangiol) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Mar. Available from http://www.ncbi.nlm.nih.gov/books/NBK476392/ PubMed PMID: 29369567.
5: Korkmaz L, Karaca C, Akin MA, Bastug O, Sahiner M, Ozdemir A, Gunes T, Ozturk MA, Kurtoglu S. Short-term Refractive Effects of Propranolol Hydrochloride Prophylaxis on Retinopathy of Prematurity in Very Preterm Newborns. Curr Eye Res. 2018 Feb;43(2):213-217. doi: 10.1080/02713683.2017.1390769. Epub 2017 Nov 14. PubMed PMID: 29135357.
