MedKoo Cat#: 563208 | Name: NGD9002

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NGD9002 is a new generation, topology 2 selective corticotropin releasing factor-1 (CRF-1) receptor antagonist.

Chemical Structure

NGD9002
CAS#666256-06-0

Theoretical Analysis

MedKoo Cat#: 563208

Name: NGD9002

CAS#: 666256-06-0

Chemical Formula: C20H31N5O

Exact Mass: 357.2529

Molecular Weight: 357.50

Elemental Analysis: C, 67.19; H, 8.74; N, 19.59; O, 4.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NGD9002; NGD-9002; NGD 9002;
IUPAC/Chemical Name
5-(6-Isopropyl-2-methylaminopyridin-3-yl)-[N-(1-ethyl)propyl]-3-methoxy-6-methylpyrazine-2-amine
InChi Key
WOFKFSYSTXMXQU-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H31N5O/c1-8-14(9-2)23-19-20(26-7)25-17(13(5)22-19)15-10-11-16(12(3)4)24-18(15)21-6/h10-12,14H,8-9H2,1-7H3,(H,21,24)(H,22,23)
SMILES Code
CC1=C(C2=CC=C(C(C)C)N=C2NC)N=C(OC)C(NC(CC)CC)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Million M, Zhao JF, Luckey A, Czimmer J, Maynard GD, Kehne J, Hoffman DC, Taché Y. The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. PLoS One. 2013 Sep 6;8(9):e73749. doi: 10.1371/journal.pone.0073749. eCollection 2013. PubMed PMID: 24040053; PubMed Central PMCID: PMC3765344.