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MedKoo Cat#: 531435 | Name: AL-8810
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

A novel analog of prostaglandin F(2alpha), AL-8810 has uniquely low efficacy (E(max)) at the endogenous prostaglandin F(2alpha) receptors (FP receptors) of A7r5 rat thoracic aorta smooth muscle cells and Swiss mouse 3T3 fibroblasts, as assayed by stimulation of phospholipase C activity. It is a selective antagonist at the prostaglandin F2 alpha (FP) receptor.

Chemical Structure

AL-8810
CAS#246246-19-5

Theoretical Analysis

MedKoo Cat#: 531435

Name: AL-8810

CAS#: 246246-19-5

Chemical Formula: C24H31FO4

Exact Mass: 402.2206

Molecular Weight: 402.51

Elemental Analysis: C, 71.62; H, 7.76; F, 4.72; O, 15.90

Price and Availability

Size Price Availability Quantity
1mg USD 300.00 2 Weeks
5mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
AL-8810, AL8810, AL 8810
IUPAC/Chemical Name
(Z)-7-[(1R,2R,3S,5S)-2-[(E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxyprop-1-enyl]-3-fluoro-5-hydroxycyclopentyl]hept-5-enoic acid
InChi Key
WTYSXBKKVNOOIX-JTGCGUAKSA-N
InChi Code
InChI=1S/C24H31FO4/c25-21-15-23(27)20(9-3-1-2-4-10-24(28)29)19(21)11-12-22(26)18-13-16-7-5-6-8-17(16)14-18/h1,3,5-8,11-12,18-23,26-27H,2,4,9-10,13-15H2,(H,28,29)/b3-1-,12-11+/t19-,20-,21+,22+,23+/m1/s1
SMILES Code
O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](C2CC3=C(C=CC=C3)C2)O)[C@@H](F)C[C@@H]1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 402.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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J Ocul Pharmacol Ther. 2006 Oct;22(5):291-309. doi: 10.1089/jop.2006.22.291. PMID: 17076623. 5: Deaver SE, Felix AM, Rhoads ML. Reproductive performance of lactating dairy cattle after intrauterine administration of a prostaglandin F2α receptor antagonist 4 days after insemination. Theriogenology. 2015 Mar 1;83(4):560-6. doi: 10.1016/j.theriogenology.2014.10.019. Epub 2014 Oct 30. PMID: 25488790. 6: Sharif NA, Crider JY, Davis TL. AL-3138 antagonizes FP prostanoid receptor- mediated inositol phosphates generation: comparison with some purported FP antagonists. J Pharm Pharmacol. 2000 Dec;52(12):1529-39. doi: 10.1211/0022357001777586. PMID: 11197083. 7: Goupil E, Wisehart V, Khoury E, Zimmerman B, Jaffal S, Hébert TE, Laporte SA. Biasing the prostaglandin F2α receptor responses toward EGFR-dependent transactivation of MAPK. Mol Endocrinol. 2012 Jul;26(7):1189-202. doi: 10.1210/me.2011-1245. Epub 2012 May 25. PMID: 22638073; PMCID: PMC5416999. 8: Woodward DF, Krauss AH, Wang JW, Protzman CE, Nieves AL, Liang Y, Donde Y, Burk RM, Landsverk K, Struble C. Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin-ethanolamides) in the feline iris. Br J Pharmacol. 2007 Feb;150(3):342-52. doi: 10.1038/sj.bjp.0706989. Epub 2006 Dec 18. PMID: 17179945; PMCID: PMC2013905. 9: Glushakov AV, Robbins SW, Bracy CL, Narumiya S, Doré S. Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury. J Neuroinflammation. 2013 Oct 30;10:132. doi: 10.1186/1742-2094-10-132. PMID: 24172576; PMCID: PMC3907016. 10: Sharif NA. Neuroaxonal and cellular damage/protection by prostanoid receptor ligands, fatty acid derivatives and associated enzyme inhibitors. Neural Regen Res. 2023 Jan;18(1):5-17. doi: 10.4103/1673-5374.343887. PMID: 35799502; PMCID: PMC9241399. 11: Cao Y, Liu Y, Dong Q, Wang T, Niu C. Alterations in the gut microbiome and metabolic profile in rats acclimated to high environmental temperature. Microb Biotechnol. 2022 Jan;15(1):276-288. doi: 10.1111/1751-7915.13772. Epub 2021 Feb 23. PMID: 33620148; PMCID: PMC8719808. 12: Dimitrova DZ, Dimitrov SD, Iliev I, Mladenov MI, Hristov KL, Mihov DN, Duridanova DB, Gagov HS. Ghrelin signaling in human mesenteric arteries. J Physiol Pharmacol. 2010 Aug;61(4):383-90. PMID: 20814065. 13: Nicotra LL, Vu M, Harvey BS, Smid SD. Prostaglandin ethanolamides attenuate damage in a human explant colitis model. Prostaglandins Other Lipid Mediat. 2013 Jan;100-101:22-9. doi: 10.1016/j.prostaglandins.2013.01.003. Epub 2013 Feb 1. PMID: 23380599. 14: Schaafsma D, Gosens R, Ris JM, Zaagsma J, Meurs H, Nelemans SA. Insulin induces airway smooth muscle contraction. Br J Pharmacol. 2007 Jan;150(2):136-42. doi: 10.1038/sj.bjp.0706985. Epub 2006 Dec 11. PMID: 17160007; PMCID: PMC2042899. 15: Roddy GW, Rinkoski TA, Monson KJ, Chowdhury UR, Fautsch MP. Stanniocalcin-1 (STC-1), a downstream effector molecule in latanoprost signaling, acts independent of the FP receptor for intraocular pressure reduction. PLoS One. 2020 May 4;15(5):e0232591. doi: 10.1371/journal.pone.0232591. PMID: 32365129; PMCID: PMC7197809. 16: Kim YT, Moon SK, Maruyama T, Narumiya S, Doré S. Prostaglandin FP receptor inhibitor reduces ischemic brain damage and neurotoxicity. Neurobiol Dis. 2012 Oct;48(1):58-65. doi: 10.1016/j.nbd.2012.06.003. Epub 2012 Jun 16. PMID: 22709986; PMCID: PMC3415285. 17: Obara K, Inaba R, Kawakita M, Murata A, Yoshioka K, Tanaka Y. Effects of NP-1815-PX, a P2X4 Receptor Antagonist, on Contractions in Guinea Pig Tracheal and Bronchial Smooth Muscles. Biol Pharm Bull. 2022;45(8):1158-1165. doi: 10.1248/bpb.b22-00234. PMID: 35908896. 18: Sharif NA. Synthetic FP-prostaglandin-induced contraction of rat uterus smooth muscle in vitro. Prostaglandins Leukot Essent Fatty Acids. 2008 Mar;78(3):199-207. doi: 10.1016/j.plefa.2008.01.005. Epub 2008 Mar 28. PMID: 18375109. 19: Maehara T, Higashitarumi F, Kondo R, Fujimori K. Prostaglandin F2α receptor antagonist attenuates LPS-induced systemic inflammatory response in mice. FASEB J. 2020 Nov;34(11):15197-15207. doi: 10.1096/fj.202001481R. Epub 2020 Sep 28. PMID: 32985737. 20: More AS, Kim HM, Zhao R, Khang G, Hildebrandt T, Bernlöhr C, Doods H, Lee D, Lee SH, Vanhoutte PM, Wu D. COX-2 mediated induction of endothelium-independent contraction to bradykinin in endotoxin-treated porcine coronary artery. J Cardiovasc Pharmacol. 2014 Sep;64(3):209-17. doi: 10.1097/FJC.0000000000000105. PMID: 25192543.