Perfluorinated SAHA | CAS#1308677-14-6 | HDAC inhibitor

MedKoo Cat#: 130135 | Name: Perfluorinated SAHA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Perfluorinated SAHA is an HDAC inhibitor for use in cancer treatment regimens, with demonstrated greater antiproliferative properties than SAHA . PFSAHA has also been shown to have higher selectivity for PA3774, an HDAC-like enzyme from P. aeruginosa, as well as other HDACs, which may prove beneficial for developing novel chemotherapeutic treatments for cancer.

Chemical Structure

Perfluorinated SAHA

CAS#1308677-14-6

Theoretical Analysis

MedKoo Cat#: 130135

Name: Perfluorinated SAHA

CAS#: 1308677-14-6

Chemical Formula: C14H8F12N2O3

Exact Mass: 480.0343

Molecular Weight: 480.21

Elemental Analysis: C, 35.02; H, 1.68; F, 47.48; N, 5.83; O, 10.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Perfluorinated SAHA; PFSAHA

IUPAC/Chemical Name

2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N1-hydroxy-N8-phenyloctanediamide

InChi Key

PVEUUUJZCFCCIZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H8F12N2O3/c15-9(16,7(29)27-6-4-2-1-3-5-6)11(19,20)13(23,24)14(25,26)12(21,22)10(17,18)8(30)28-31/h1-5,31H,(H,27,29)(H,28,30)

SMILES Code

O=C(NO)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(NC1=CC=CC=C1)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 480.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Walton JW, Cross JM, Riedel T, Dyson PJ. Perfluorinated HDAC inhibitors as selective anticancer agents. Org Biomol Chem. 2017 Nov 7;15(43):9186-9190. doi: 10.1039/c7ob02339a. PMID: 29072756. 2. Meyners C, Wolff B, Kleinschek A, Krämer A, Meyer-Almes FJ. Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa. Bioorg Med Chem Lett. 2017 Apr 1;27(7):1508-1512. doi: 10.1016/j.bmcl.2017.02.050. Epub 2017 Feb 21. PMID: 28259626. 3. Henkes LM, Haus P, Jäger F, Ludwig J, Meyer-Almes FJ. Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases. Bioorg Med Chem. 2012 Jan 15;20(2):985-95. doi: 10.1016/j.bmc.2011.11.041. Epub 2011 Nov 30. PMID: 22182579.