Synonym
Clidinium; N-Methyl quinuclidinyl benzilate; Clidinium ion; Clidinium cation
IUPAC/Chemical Name
1-Azoniabicyclo(2.2.2)octane, 3-((hydroxydiphenylacetyl)oxy)-1-methyl-
InChi Key
HOOSGZJRQIVJSZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1
SMILES Code
C[N+]1(CC2)CC(OC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)=O)C2CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
352.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Puasripun S, Thinrungroj N, Pinyopornpanish K, Kijdamrongthum P, Leerapun A, Chitapanarux T, Thongsawat S, Praisontarangkul OA. Efficacy and Safety of Clidinium/Chlordiazepoxide as an Add-on Therapy in Functional Dyspepsia: A Randomized, Controlled, Trial. J Neurogastroenterol Motil. 2020 Apr 30;26(2):259-266. doi: 10.5056/jnm19186. PMID: 32235033; PMCID: PMC7176503.
2: Seyyedmajidi M, Homapoor S, Zanganeh E, Dadjou M, Eskandari Nejad S, Tajik Galayeri MH, Vafaeimanesh J. Addition of clidinium-C to the 14-day proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication. Caspian J Intern Med. 2016 Spring;7(2):78-81. PMID: 27386057; PMCID: PMC4913708.
3: Nessim CK, Michael AM, Fayez YM, Lotfy HM. Novel Stability-Indicating Chemometric-Assisted Spectrophotometric Methods for the Determination of Chlordiazepoxide and Clidinium Bromide in the Presence of Clidinium Bromide's Alkali-Induced Degradation Product. J AOAC Int. 2018 May 1;101(3):714-722. doi: 10.5740/jaoacint.17-0096. Epub 2017 Sep 19. PMID: 28927485.
4: Richardson SE, Edwards K. Accidental acute clidinium toxicity. Emerg Med J. 2009 Jun;26(6):460. doi: 10.1136/emj.2008.067926. PMID: 19465630.
5: Chorami M, Zojaji H, Naderi N, Moghimi-Dehkordi B, Mirsattari D, Shalmani HM. Evaluation of the benefit of addition of clidinium C to a Helicobacter pylori eradication regimen. Gastroenterol Hepatol Bed Bench. 2013 Summer;6(3):141-5. PMID: 24834261; PMCID: PMC4017509.
6: Ashour S, Kattan N. Simultaneous Determination of Clidinium Bromide and Chlordiazepoxide in Combined Dosage Forms by High-Performance Liquid Chromatography. J Pharm (Cairo). 2013;2013:417682. doi: 10.1155/2013/417682. Epub 2013 Feb 24. PMID: 26555978; PMCID: PMC4590797.
7: Khoshayand MR, Abdollahi H, Moeini A, Shamsaie A, Ghaffari A, Abbasian S. Simultaneous spectrophotometric determination of chlordiazepoxide and clidinium using multivariate calibration techniques. Drug Test Anal. 2010 Sep;2(9):430-5. doi: 10.1002/dta.162. PMID: 20812297.
8: Pathak A, Rai P, Rajput SJ. Stability-indicating HPLC method for simultaneous determination of clidinium bromide and chlordiazepoxide in combined dosage forms. J Chromatogr Sci. 2010 Mar;48(3):235-9. doi: 10.1093/chromsci/48.3.235. PMID: 20223092.
9: Nickerson B. The determination of a degradation product in clidinium bromide drug substance by capillary electrophoresis with indirect UV detection. J Pharm Biomed Anal. 1997 Apr;15(7):965-71. doi: 10.1016/s0731-7085(96)01922-x. PMID: 9160263.
10: Moezi L, Pirsalami F, Inaloo S. Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice. Epilepsy Behav. 2015 Mar;44:200-6. doi: 10.1016/j.yebeh.2015.01.013. Epub 2015 Mar 6. PMID: 25745976.
