MedKoo Cat#: 463070 | Name: SOP1812

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SOP1812 is a novel quadruplex ligand, down-regulating several cancer gene pathways, including Wnt/β-catenin signaling, showing potent activity in pancreatic cancer models.

Chemical Structure

SOP1812
SOP1812
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463070

Name: SOP1812

CAS#: unknown

Chemical Formula: C45H58N8O6

Exact Mass: 806.4479

Molecular Weight: 807.01

Elemental Analysis: C, 66.98; H, 7.24; N, 13.89; O, 11.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SOP1812; SOP 1812; SOP-1812;
IUPAC/Chemical Name
2,7-bis(3-morpholinopropyl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)-9-((4-(pyrrolidin-1-ylmethyl)phenyl)amino)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone
InChi Key
KTGDGRJNPRWCFQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C45H58N8O6/c54-42-34-29-36(46-11-20-48-12-1-2-13-48)40-38-35(43(55)52(44(40)56)18-5-16-49-21-25-58-26-22-49)30-37(47-33-9-7-32(8-10-33)31-51-14-3-4-15-51)41(39(34)38)45(57)53(42)19-6-17-50-23-27-59-28-24-50/h7-10,29-30,46-47H,1-6,11-28,31H2
SMILES Code
O=C(N(CCCN1CCOCC1)C2=O)C3=C(NC4=CC=C(CN5CCCC5)C=C4)C=C6C7=C3C2=CC(NCCN8CCCC8)=C7C(N(CCCN9CCOCC9)C6=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 807.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ahmed AA, Angell R, Oxenford S, Worthington J, Williams N, Barton N, Fowler TG, O'Flynn DE, Sunose M, McConville M, Vo T, Wilson WD, Karim SA, Morton JP, Neidle S. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. ACS Med Chem Lett. 2020 Jul 16;11(8):1634-1644. doi: 10.1021/acsmedchemlett.0c00317. PMID: 32832034; PMCID: PMC7429975.