Synonym
Diclofensine; Diclofensina; Ro 8-4650; Ro-8-4650; Ro8-4650; Ro 84650; Ro-84650; Ro84650;
IUPAC/Chemical Name
Isoquinoline, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methyl-
InChi Key
ZJDCGVDEEHWEIG-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H17Cl2NO/c1-20-9-12-7-13(21-2)4-5-14(12)15(10-20)11-3-6-16(18)17(19)8-11/h3-8,15H,9-10H2,1-2H3
SMILES Code
CN1CC2=C(C=CC(OC)=C2)C(C3=CC=C(Cl)C(Cl)=C3)C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
322.23
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Luethi D, Hoener MC, Liechti ME. Effects of the new psychoactive substances diclofensine, diphenidine, and methoxphenidine on monoaminergic systems. Eur J Pharmacol. 2018 Jan 15;819:242-247. doi: 10.1016/j.ejphar.2017.12.012. Epub 2017 Dec 7. PMID: 29225192.
2: Jackson SH, Turner P, Ehsanullah RS. A comparison of diclofensine and desmethylimipramine using tyramine pressor tests in normal subjects. Br J Clin Pharmacol. 1983 Oct;16(4):427-9. doi: 10.1111/j.1365-2125.1983.tb02189.x. PMID: 6626436; PMCID: PMC1428037.
3: Capponi R, Hormazabal L, Schmid-Burgk W. Diclofensine and imipramine. A double-blind comparative trial in depressive out-patients. Neuropsychobiology. 1985;14(4):173-80. doi: 10.1159/000118224. PMID: 3915058.
4: Manna SK, Panda G. Synthesis of enantiomerically enriched indolines and tetrahydroisoquinolines from (S)-amino acid-derived chiral carbocations: an easy access to (3S,4R)-demethoxy-3-isopropyl diclofensine. Org Biomol Chem. 2014 Nov 7;12(41):8318-24. doi: 10.1039/c4ob00922c. Epub 2014 Sep 11. PMID: 25208820.
5: Jansen W, Brückner GW, Henauer S, Omer LM. Klinischer Doppelblindvergleich von Diclofensin und Plazebo bei geriatrischen Patienten mit depressiven Verstimmungszuständen [Clinical double blind comparison of diclofensine and placebo in geriatric patients with depressive syndromes]. Pharmacopsychiatria. 1982 Nov;15(6):205-9. German. doi: 10.1055/s-2007-1019539. PMID: 6760217.
6: Strojny N, de Silva JA. Determination of diclofensine, an antidepressant agent, and its major metabolites in human plasma by high-performance liquid chromatography with fluorometric detection. J Chromatogr. 1985 Jun 14;341(2):313-31. doi: 10.1016/s0378-4347(00)84045-1. PMID: 4030982.
7: Omer OL, Díaz-Olivera M, Ismail S. Therapeutic efficacy and tolerance of diclofensine in psychoreactive depression--a double-blind comparison with placebo. Methods Find Exp Clin Pharmacol. 1984 Mar;6(3):147-51. PMID: 6379345.
8: Cherpillod C, Omer LM. A controlled trial with diclofensine, a new psychoactive drug, in the treatment of depression. J Int Med Res. 1981;9(5):324-9. doi: 10.1177/030006058100900505. PMID: 7028532.
9: Lamb RJ, Griffiths RR. Self-administration in baboons and the discriminative stimulus effects in rats of bupropion, nomifensine, diclofensine and imipramine. Psychopharmacology (Berl). 1990;102(2):183-90. doi: 10.1007/BF02245920. PMID: 2125734.
10: Gasić S, Korn A, Eichler HG. Effect of diclofensine, a novel antidepressant, on peripheral adrenergic function. Clin Pharmacol Ther. 1986 May;39(5):582-5. doi: 10.1038/clpt.1986.100. PMID: 3698467.
