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MedKoo Cat#: 317542 | Name: Clidinium Bromide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clidinium bromide is an anticholinergic drug, specifically a muscarinic antagonist. It may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines. It is commonly prescribed in combination with chlordiazepoxide using the brand name Librax.

Chemical Structure

Clidinium Bromide
Clidinium Bromide
CAS#3485-62-9 (Bromide)

Theoretical Analysis

MedKoo Cat#: 317542

Name: Clidinium Bromide

CAS#: 3485-62-9 (Bromide)

Chemical Formula: C22H26BrNO3

Exact Mass: 0.0000

Molecular Weight: 432.35

Elemental Analysis: C, 61.12; H, 6.06; Br, 18.48; N, 3.24; O, 11.10

Price and Availability

Size Price Availability Quantity
500mg USD 285.00 2 Weeks
1g USD 485.00 2 Weeks
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Related CAS #
7020-55-5 (cation) 3485-62-9 (Bromide)
Synonym
Clidinium Bromide; Clidinium Br; Quarzan bromide; Ro 2-3773; Ro2-3773; Ro-2-3773;
IUPAC/Chemical Name
(1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) 2-hydroxy-2,2-diphenylacetate;bromide
InChi Key
GKEGFOKQMZHVOW-UHFFFAOYSA-M
InChi Code
InChI=1S/C22H26NO3.BrH/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19;/h2-11,17,20,25H,12-16H2,1H3;1H/q+1;/p-1
SMILES Code
C[N+]12CCC(CC1)C(C2)OC(=O)C(C3=CC=CC=C3)(C4=CC=CC=C4)O.[Br-]
Appearance
White to off-white crystalline powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 432.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nessim CK, Michael AM, Fayez YM, Lotfy HM. Novel Stability-Indicating Chemometric-Assisted Spectrophotometric Methods for the Determination of Chlordiazepoxide and Clidinium Bromide in the Presence of Clidinium Bromide's Alkali-Induced Degradation Product. J AOAC Int. 2018 May 1;101(3):714-722. doi: 10.5740/jaoacint.17-0096. Epub 2017 Sep 19. PMID: 28927485. 2: Toral MI, Richter P, Lara N, Jaque P, Soto C, Saavedra M. Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry. Int J Pharm. 1999 Oct 28;189(1):67-74. doi: 10.1016/s0378-5173(99)00238-0. PMID: 10518686. 3: Yuen SM, Lehr G. Liquid chromatographic determination of clidinium bromide and clidinium bromide-chlordiazepoxide hydrochloride combinations in capsules. J Assoc Off Anal Chem. 1991 May-Jun;74(3):461-4. PMID: 1874688. 4: Richardson SE, Edwards K. Accidental acute clidinium toxicity. Emerg Med J. 2009 Jun;26(6):460. doi: 10.1136/emj.2008.067926. PMID: 19465630. 5: Vuignier BI, Oderda GM, Gorman RL, Klein-Schwartz W, Watson WA. Effects of magnesium citrate and clidinium bromide on the excretion of activated charcoal in normal subjects. DICP. 1989 Jan;23(1):26-9. doi: 10.1177/106002808902300104. PMID: 2718479. 6: Ashour S, Kattan N. Simultaneous Determination of Clidinium Bromide and Chlordiazepoxide in Combined Dosage Forms by High-Performance Liquid Chromatography. J Pharm (Cairo). 2013;2013:417682. doi: 10.1155/2013/417682. Epub 2013 Feb 24. PMID: 26555978; PMCID: PMC4590797. 7: Pathak A, Rai P, Rajput SJ. Stability-indicating HPLC method for simultaneous determination of clidinium bromide and chlordiazepoxide in combined dosage forms. J Chromatogr Sci. 2010 Mar;48(3):235-9. doi: 10.1093/chromsci/48.3.235. PMID: 20223092. 8: Nickerson B. The determination of a degradation product in clidinium bromide drug substance by capillary electrophoresis with indirect UV detection. J Pharm Biomed Anal. 1997 Apr;15(7):965-71. doi: 10.1016/s0731-7085(96)01922-x. PMID: 9160263. 9: Seyyedmajidi M, Homapoor S, Zanganeh E, Dadjou M, Eskandari Nejad S, Tajik Galayeri MH, Vafaeimanesh J. Addition of clidinium-C to the 14-day proton-pump inhibitor-based triple therapy for Helicobacter pylori eradication. Caspian J Intern Med. 2016 Spring;7(2):78-81. PMID: 27386057; PMCID: PMC4913708. 10: Puasripun S, Thinrungroj N, Pinyopornpanish K, Kijdamrongthum P, Leerapun A, Chitapanarux T, Thongsawat S, Praisontarangkul OA. Efficacy and Safety of Clidinium/Chlordiazepoxide as an Add-on Therapy in Functional Dyspepsia: A Randomized, Controlled, Trial. J Neurogastroenterol Motil. 2020 Apr 30;26(2):259-266. doi: 10.5056/jnm19186. PMID: 32235033; PMCID: PMC7176503. 11: Khoshayand MR, Abdollahi H, Moeini A, Shamsaie A, Ghaffari A, Abbasian S. Simultaneous spectrophotometric determination of chlordiazepoxide and clidinium using multivariate calibration techniques. Drug Test Anal. 2010 Sep;2(9):430-5. doi: 10.1002/dta.162. PMID: 20812297. 12: Chorami M, Zojaji H, Naderi N, Moghimi-Dehkordi B, Mirsattari D, Shalmani HM. Evaluation of the benefit of addition of clidinium C to a Helicobacter pylori eradication regimen. Gastroenterol Hepatol Bed Bench. 2013 Summer;6(3):141-5. PMID: 24834261; PMCID: PMC4017509. 13: Blum A. Salicylate-induced delirium? Psychosomatics. 1987 Jul;28(7):344. doi: 10.1016/S0033-3182(87)72503-1. PMID: 3438450. 14: Moezi L, Pirsalami F, Inaloo S. Constipation enhances the propensity to seizure in pentylenetetrazole-induced seizure models of mice. Epilepsy Behav. 2015 Mar;44:200-6. doi: 10.1016/j.yebeh.2015.01.013. Epub 2015 Mar 6. PMID: 25745976. 15: Lonare S, Sharma M, Dalal V, Gubyad M, Kumar P, Nath Gupta D, Pareek A, Tomar S, Kumar Ghosh D, Kumar P, Kumar Sharma A. Identification and evaluation of potential inhibitor molecules against TcyA from Candidatus Liberibacter asiaticus. J Struct Biol. 2023 Jun 30;215(3):107992. doi: 10.1016/j.jsb.2023.107992. Epub ahead of print. PMID: 37394197. 16: WARSHAW LJ, BENNETT HJ, CHASSAN JB. CHLORDIAZEPOXIDE AND CLIDINIUM BROMIDE IN MANAGEMENT OF ACUTE GASTROINTESTINAL UPSET. N Y State J Med. 1964 Feb 1;64:405-9. PMID: 14118316. 17: Hurwitz A, Robinson RG, Herrin WF, Christie J. Oral anticholinergics and gastric emptying. Clin Pharmacol Ther. 1982 Feb;31(2):168-74. doi: 10.1038/clpt.1982.26. PMID: 6895722. 18: Ehrlich R. Analysis of premedication for sigmoidoscopy: a comparative study with chlordiazepoxide alone and in combination with clidinium bromide. Am J Proctol. 1969 Apr;20(2):130-3. PMID: 5818877. 19: Copé R. Etude clinique comparative de l'association Clidinium (br)-chlordiazepoxide et de la trimebutine dans le traitement des colopathies fonctionnelles [Comparative clinical study of the combination of clidinium(br)-chlordiazepoxide and trimebutine in the treatment of functional colopathies]. Med Chir Dig. 1981;10(8):713-7. French. PMID: 6896078. 20: SCALITI GC. [Clinical trials of Librax Roche (clidinium bromide with methamino diazepoxide) in some diseases of the digestive tract]. Minerva Med. 1962 Apr 18;53:1184-9. Italian. PMID: 14497768.