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MedKoo Cat#: 125402 | Name: Tifluadom HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tifluadom is a kappa-opioid benzodiazepine.

Chemical Structure

Tifluadom HCl
Tifluadom HCl
CAS#96337-50-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 125402

Name: Tifluadom HCl

CAS#: 96337-50-7 (HCl)

Chemical Formula: C22H21ClFN3OS

Exact Mass: 429.1100

Molecular Weight: 429.94

Elemental Analysis: C, 61.46; H, 4.92; Cl, 8.25; F, 4.42; N, 9.77; O, 3.72; S, 7.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
96337-50-7 (HCl) 83386-35-0 (free base)
Synonym
Tifluadom Hydrochloride; 96337-50-7; RQB9JWT8M3; DTXSID80858485
IUPAC/Chemical Name
N-((5-(2-fluorophenyl)-1-methyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methyl)thiophene-3-carboxamide hydrochloride
InChi Key
JFZSUQQSHDYRGA-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H20FN3OS.ClH/c1-26-16(13-25-22(27)15-10-11-28-14-15)12-24-21(17-6-2-4-8-19(17)23)18-7-3-5-9-20(18)26;/h2-11,14,16H,12-13H2,1H3,(H,25,27);1H
SMILES Code
Cl.CN1C(CNC(=O)C2=CSC=C2)CN=C(C3=CC=CC=C3F)C4=CC=CC=C14
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 429.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Genovese RF, Dykstra LA. Tifluadom's effects under electric shock titration and tail-immersion procedures in squirrel monkeys. Life Sci. 1986 Nov 10;39(19):1713-9. PubMed PMID: 3773641. 2: Gericke M, Morgenstern R, Ott T. The influence of tifluadom on cholecystokinin-induced antinociception. Eur J Pharmacol. 1990 May 3;180(1):187-90. PubMed PMID: 2365002. 3: Cooper SJ, Moores WR, Jackson A, Barber DJ. Effects of tifluadom on food consumption compared with chlordiazepoxide and kappa agonists in the rat. Neuropharmacology. 1985 Sep;24(9):877-83. PubMed PMID: 2997653. 4: Das S, Bhargava HN. Inhibition of [3H][3-MeHis2]thyrotropin releasing hormone recognition sites in the rat brain by tifluadom, a kappa opiate receptor agonist. Neuropharmacology. 1987 Aug;26(8):1141-6. PubMed PMID: 2889163. 5: Shearman GT, Tolcsvai L. Tifluadom-induced diuresis in rats. Evidence for an opioid receptor-mediated central action. Neuropharmacology. 1986 Aug;25(8):853-6. PubMed PMID: 3022178. 6: Chang RS, Lotti VJ, Chen TB, Keegan ME. Tifluadom, a kappa-opiate agonist, acts as a peripheral cholecystokinin receptor antagonist. Neurosci Lett. 1986 Dec 12;72(2):211-4. PubMed PMID: 3027627. 7: Benton D, Smoothy R, Brain PF. Comparisons of the influence of morphine sulphate, morphine-3-glucuronide and tifluadom on social encounters in mice. Physiol Behav. 1985 Nov;35(5):689-93. PubMed PMID: 3001798. 8: Pavone F, Castellano C. Effects of tifluadom on passive avoidance behaviour in DBA/2 mice. Behav Brain Res. 1985 May;15(3):177-81. PubMed PMID: 2988580. 9: Morley JE, Levine AS, Grace M, Kneip J, Zeugner H. The effect of the opioid-benzodiazepine, tifluadom, on ingestive behaviors. Eur J Pharmacol. 1983 Sep 30;93(3-4):265-9. PubMed PMID: 6315453. 10: Murray C, Cowan A. Neuroadaptation of rats to kappa agonists U-50,488 and tifluadom. NIDA Res Monogr. 1988;81:136-42. PubMed PMID: 2841602. 11: Ureta H, López LF, Pérez A, Huidobro-Toro JP. Kappa-opiate-induced diuresis and changes in blood pressure: demonstration of receptor stereoselectivity using (+)- and (-)-tifluadom. Eur J Pharmacol. 1987 Mar 31;135(3):289-95. PubMed PMID: 3034631. 12: Petrillo P, Amato M, Tavani A. The interaction of the two isomers of the opioid benzodiazepine tifluadom with mu-, delta-, and kappa-binding sites and their analgesic and intestinal effects in rats. Neuropeptides. 1985 Feb;5(4-6):403-6. PubMed PMID: 2860598. 13: Jackson HC, Sewell RD. The role of opioid receptor sub-types in tifluadom-induced feeding. J Pharm Pharmacol. 1984 Oct;36(10):683-6. PubMed PMID: 6150086. 14: Upton N, Gonzalez JP, Sewell RD. Characterization of a kappa-agonist-like antinociceptive action of tifluadom. Neuropharmacology. 1983 Oct;22(10):1241-2. PubMed PMID: 6316195. 15: Järvinen A. Atipamezole, benzodiazepines, bicucullin and tifluadom antagonize the effect of TRH on rat duodenum and displace it from brain and anterior pituitary receptors. Pharmacol Toxicol. 1991 May;68(5):371-9. PubMed PMID: 1658766. 16: Burkard WP, Müller PM, Flück N. Characteristics of 3H-tifluadom binding in guinea-pig brain membranes. J Recept Res. 1984;4(1-6):165-73. PubMed PMID: 6151988. 17: Leander JD. Kappa-opioid diuretic effects of tifluadom, a benzodiazepine opioid agonist. J Pharm Pharmacol. 1984 Aug;36(8):555-6. PubMed PMID: 6148404. 18: Sansone M, Castellano C, Pavone F, Hano J. Opioid benzodiazepine tifluadom and drug-induced hyperactivity in mice: lack of benzodiazepine-like effects. Pol J Pharmacol Pharm. 1985 Sep-Oct;37(5):585-90. PubMed PMID: 2870483. 19: Beck T, Krieglstein J. The effects of tifluadom and ketazocine on behaviour, dopamine turnover in the basal ganglia and local cerebral glucose utilization of rats. Brain Res. 1986 Sep 3;381(2):327-35. PubMed PMID: 3756508. 20: Hill HF, Watanabe Y, Shibuya T. Differential, postnatal ontogeny of opiate and benzodiazepine receptor subtypes in rat cerebral cortex: binding characteristics of tifluadom and brotizolam. Jpn J Pharmacol. 1984 Sep;36(1):15-21. PubMed PMID: 6094900.