Synonym
TPN729; TPN 729; TPN-729;
IUPAC/Chemical Name
4-ethoxy-N-methyl-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide
InChi Key
ZXPWZSOTCAPVCQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H34N6O4S/c1-5-9-19-21-22(29(4)27-19)24(31)26-23(25-21)18-16-17(10-11-20(18)34-6-2)35(32,33)28(3)14-15-30-12-7-8-13-30/h10-11,16H,5-9,12-15H2,1-4H3,(H,25,26,31)
SMILES Code
O=S(C1=CC(C2=NC(C(CCC)=NN3C)=C3C(N2)=O)=C(OCC)C=C1)(N(C)CCN4CCCC4)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
502.63
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tian QQ, Zhu YT, Diao XX, Zhang XL, Xu YC, Jiang XR, Shen JS, Wang Z, Zhong DF. Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor. Acta Pharmacol Sin. 2020 Jun 24. doi: 10.1038/s41401-020-0447-x. Epub ahead of print. PMID: 32581257.
2: Liu Y, Shao S, Song H, Yao X, Liu J, Liu H, Song L, Jiang J, Liu D, Hu P. Simultaneous determination of TPN729 and its five metabolites in human plasma and urine by liquid chromatography coupled to tandem mass spectrometry. J Pharm Biomed Anal. 2018 Mar 20;151:91-105. doi: 10.1016/j.jpba.2017.12.057. Epub 2017 Dec 30. PMID: 29310052.
3: Zhu Y, Li L, Deng P, Chen X, Zhong D. Characterization of TPN729 metabolites in humans using ultra-performance liquid chromatography/quadrupole time-of- flight mass spectrometry. J Pharm Biomed Anal. 2016 Jan 5;117:217-26. doi: 10.1016/j.jpba.2015.09.001. Epub 2015 Sep 3. PMID: 26366939.
