Nemiralisib succinate | CAS# 1364799-98-3 | Biochemical

MedKoo Cat#: 576038 | Name: Nemiralisib succinate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nemiralisib succinate is a potent and selective PI3Kδ inhibitor.

Chemical Structure

Nemiralisib succinate

CAS#1364799-98-3

Theoretical Analysis

MedKoo Cat#: 576038

Name: Nemiralisib succinate

CAS#: 1364799-98-3

Chemical Formula: C56H62N12O6

Exact Mass: 998.4915

Molecular Weight: 999.19

Elemental Analysis: C, 67.32; H, 6.25; N, 16.82; O, 9.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GSK2269557H; GSK 2269557H; GSK-2269557H; Nemiralisib succinate

IUPAC/Chemical Name

Butanedioic acid, compd. with 6-(1H-indol-4-yl)-4-(5-((4-(1-methylethyl)-1-piperazinyl)methyl)-2-oxazolyl)-1H-indazole (1:2)

InChi Key

MEBXGOVBBDIMBC-UHFFFAOYSA-N

InChi Code

InChI=1S/2C26H28N6O.C4H6O4/c2*1-17(2)32-10-8-31(9-11-32)16-19-14-28-26(33-19)22-12-18(13-25-23(22)15-29-30-25)20-4-3-5-24-21(20)6-7-27-24;5-3(6)1-2-4(7)8/h2*3-7,12-15,17,27H,8-11,16H2,1-2H3,(H,29,30);1-2H2,(H,5,6)(H,7,8)

SMILES Code

CC(C)N1CCN(Cc2oc(nc2)c3cc(cc4[nH]ncc34)c5cccc6[nH]ccc56)CC1.CC(C)N7CCN(Cc8oc(nc8)c9cc(cc%10[nH]ncc9%10)c%11cccc%12[nH]ccc%11%12)CC7.OC(=O)CCC(=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 999.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Down KD, Amour A, Baldwin IR, Cooper AW, Deakin AM, Felton LM, Guntrip SB, Hardy C, Harrison ZA, Jones KL, Jones P, Keeling SE, Le J, Livia S, Lucas F, Lunniss CJ, Parr NJ, Robinson E, Rowland P, Smith S, Thomas DA, Vitulli G, Washio Y, Hamblin N. Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinostide-3-Kinase Delta for the Treatment of Respiratory Disease. J Med Chem. 2015 Aug 24. [Epub ahead of print] PubMed PMID: 26301626.