TPOP146 is a potent and selective CBP/P300 Benzoxazepine Bromodomain Inhibitor. TPOP146 showed 134 nM affinity for CBP with excellent selectivity over other bromodomains. Deregulation of CBP/P300 has been reported in cancer and chromosomal rearrangement of the CBP/P300 locus results in oncogenic fusions with either MOZ acetyltransferase or the mixed linage leukemia (MLL) gene product and CBP/MLL fusions have been detected in acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) after treatment with topoisomerase inhibitors.
MedKoo Cat#: 406826
Name: TPOP146
CAS#: 2018300-62-2
Chemical Formula: C27H35N3O5
Exact Mass: 481.2577
Molecular Weight: 481.59
Elemental Analysis: C, 67.34; H, 7.33; N, 8.73; O, 16.61
The following data is based on the product molecular weight 481.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
