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MedKoo Cat#: 592389 | Name: Acrinor

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Acrinor is a adrenergic beta receptor agonist.

Chemical Structure

Acrinor
CAS#8004-31-7

Theoretical Analysis

MedKoo Cat#: 592389

Name: Acrinor

CAS#: 8004-31-7

Chemical Formula: C35H46Cl2N10O8

Exact Mass: 804.2877

Molecular Weight: 804.72

Elemental Analysis: C, 52.18; H, 5.75; Cl, 8.80; N, 17.38; O, 15.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Acrinor; H 835
IUPAC/Chemical Name
Systematic Name 1H-Purine-2,6-dione, 3,7-dihydro-7-(2-(((1S,2R)-2-hydroxy-1-methyl-2-phenylethyl)amino)ethyl)-1,3-dimethyl-, monohydrochloride, mixt. with 7-(2-((2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)amino)ethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrochloride
InChi Key
RUUVZJIVMZGFMN-OMTSWVOZSA-N
InChi Code
InChI=1S/C18H23N5O3.C17H21N5O5.2ClH/c1-12(15(24)13-7-5-4-6-8-13)19-9-10-23-11-20-16-14(23)17(25)22(3)18(26)21(16)2;1-20-15-14(16(26)21(2)17(20)27)22(9-19-15)6-5-18-8-13(25)10-3-4-11(23)12(24)7-10;;/h4-8,11-12,15,19,24H,9-10H2,1-3H3;3-4,7,9,13,18,23-25H,5-6,8H2,1-2H3;2*1H/t12-,15-;13-;;/m01../s1
SMILES Code
O[C@H](c1ccccc1)[C@H](C)NCCn(cn2)c3c2n(C)c(n(C)c3=O)=O.O=c4c(n(CCNC[C@H](c5ccc(O)c(O)c5)O)cn6)c6n(C)c(n4C)=O.Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 804.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Heller AR, Heger J, Gama de Abreu M, Müller MP. Cafedrine/theodrenaline in anaesthesia: influencing factors in restoring arterial blood pressure. Anaesthesist. 2015 Mar;64(3):190-6. doi: 10.1007/s00101-015-0005-y. Epub 2015 Mar 11. PubMed PMID: 25757552; PubMed Central PMCID: PMC4383809. 2: Clemens KE, Quednau I, Heller AR, Klaschik E. Impact of cafedrine/theodrenaline (Akrinor® ) on therapy of maternal hypotension during spinal anesthesia for Cesarean delivery: a retrospective study. Minerva Ginecol. 2010 Dec;62(6):515-24. PubMed PMID: 21079573. 3: Schirmer U, Schürmann W. [Preoperative administration of angiotensin-converting enzyme inhibitors]. Anaesthesist. 2007 Jun;56(6):557-61. German. PubMed PMID: 17435976. 4: Aniset L, Konrad C, Schley M. [Ephedrine as alternative to Akrinor in regional obstetric anesthesia]. Anaesthesist. 2006 Jul;55(7):784-90. Review. German. PubMed PMID: 16688428. 5: Usichenko TI, Foellner S, Gruendling M, Feyerherd F, Lehmann C, Wendt M, Pavlovic D. Akrinor-induced relaxation of pig coronary artery in vitro is transformed into alpha1-adrenoreceptor-mediated contraction by pretreatment with propranolol. J Cardiovasc Pharmacol. 2006 Mar;47(3):450-5. PubMed PMID: 16633089. 6: Koch T, Wenzel V. [Old drugs and new approval procedures: Akrinor remains marketable and an application for reapproval of Arginin Vasopressin has been made]. Anaesthesist. 2006 Jun;55(6):708-10. German. PubMed PMID: 16612644. 7: Weidemann F, Broscheit JA, Bijnens B, Claus P, Sutherland GR, Voelker W, Ertl G, Strotmann JM. How to distinguish between ischemic and nonischemic postsystolic thickening: a strain rate imaging study. Ultrasound Med Biol. 2006 Jan;32(1):53-9. PubMed PMID: 16364797. 8: Broscheit J, Eichelbroenner O, Greim C, Bussen S. Anesthetic management of a patient with histiocytosis X and pulmonary complications during Caesarean section. Eur J Anaesthesiol. 2004 Nov;21(11):919-21. PubMed PMID: 15717713. 9: Kampe S, Nori H, Schneider PM, Krott R. [Mydriasis not reacting to light during an uneventful esophagectomy--drug-related side effect of Akrinor?]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2003 Mar;38(3):165-7. German. PubMed PMID: 12635042. 10: Niesel HC, Klimpel L, Kaiser H, Bernhardt A, al-Rafai S, Lang U. [Epidural blockade for analgesia and treatment of acute pancreatitis]. Reg Anaesth. 1991 Dec;14(6):97-100. German. PubMed PMID: 1780489. 11: Boldt J, Müller H, Börner U, Kling D, Moosdorf R, Hempelmann G. [Isolated modification of the vascular system by vasopressor agents (akrinor, etilefrin, ephedrine, norfenefrine, amezinium) during extracorporeal circulation in man]. Anaesthesist. 1986 Feb;35(2):93-8. German. PubMed PMID: 2870661. 12: Dubova MN. [Correction of cardiovascular hypodynamics in the early postoperative period with the adrenergic beta receptor agonist acrinor]. Anesteziol Reanimatol. 1981 Sep-Oct;(5):21-4. Russian. PubMed PMID: 6119935. 13: Oliva I, Levy B, Martineaud JP. [Hemodynamic effects of Praxinor on the peripheral circulation (author's transl)]. Sem Hop. 1981 May 18-25;57(19-20):1034-8. French. PubMed PMID: 6266024. 14: Reichelt W, Piepenbrock S, Hempelmann G, Oelert H. [The effects of Akrinor on the extrathoracic capacitance vessels during extracorporeal circulation and on cardiac haemodynamics of anaesthetized man (author's transl)]. Anaesthesist. 1980 Sep;29(9):481-6. German. PubMed PMID: 7468988. 15: Jedlicka K, Krofta K, Nikodýmová L. [Effect of Acrinor on various functions of the cardiovascular system and lungs]. Cas Lek Cesk. 1973 Jan 19;112(3):80-3. Czech. PubMed PMID: 4405272. 16: STERNITZKE N. [THE CARDIOVASCULAR EFFECT OF AKRINOR, A CIRCULATORY ANALEPTIC WITH LONG-TERM EFFECT]. Z Kreislaufforsch. 1965 Jan;54:10-8. German. PubMed PMID: 14274668. 17: EICHLER J, STEPHAN G. [CLINICAL AND EXPERIMENTAL ANIMAL STUDIES WITH THE CIRCULATORY ANALEPTIC, AMINOALKYLTHEOPHYLLINE (AKRINOR), IN NORMOTHERMIA AND HYPOTHERMIA]. Anaesthesist. 1964 Aug;13:254-6. German. PubMed PMID: 14309434.