Synonym
Omigapil (free base); CGP3466; CGP-3466; CGP 3466
IUPAC/Chemical Name
N-(dibenzo[b,f]oxepin-10-ylmethyl)-N-methylprop-2-yn-1-amine
InChi Key
QLMMOGWZCFQAPU-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H17NO/c1-3-12-20(2)14-16-13-15-8-4-6-10-18(15)21-19-11-7-5-9-17(16)19/h1,4-11,13H,12,14H2,2H3
SMILES Code
CN(CC1=Cc2c(Oc3c1cccc3)cccc2)CC#C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
275.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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5: Meinen S, Lin S, Thurnherr R, Erb M, Meier T, Rüegg MA. Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO Mol Med. 2011 Aug;3(8):465-79. doi: 10.1002/emmm.201100151. Epub 2011 Jun 15. PMID: 21674808; PMCID: PMC3377088.
6: Sarkozy A, Foley AR, Zambon AA, Bönnemann CG, Muntoni F. LAMA2-Related Dystrophies: Clinical Phenotypes, Disease Biomarkers, and Clinical Trial Readiness. Front Mol Neurosci. 2020 Aug 5;13:123. doi: 10.3389/fnmol.2020.00123. PMID: 32848593; PMCID: PMC7419697.
7: Harraz MM, Snyder SH. Nitric Oxide-GAPDH Transcriptional Signaling Mediates Behavioral Actions of Cocaine. CNS Neurol Disord Drug Targets. 2015;14(6):757-63. doi: 10.2174/1871527314666150529150143. PMID: 26022259; PMCID: PMC4831565.
8: Yacoubian TA, Standaert DG. Targets for neuroprotection in Parkinson's disease. Biochim Biophys Acta. 2009 Jul;1792(7):676-87. doi: 10.1016/j.bbadis.2008.09.009. Epub 2008 Oct 1. PMID: 18930814; PMCID: PMC2740981.
9: LeWitt PA. Clinical trials of neuroprotection for Parkinson's disease. Neurology. 2004 Oct 12;63(7 Suppl 2):S23-31. doi: 10.1212/wnl.63.7_suppl_2.s23. PMID: 15477583.
10: Snider NT, Portney DA, Willcockson HH, Maitra D, Martin HC, Greenson JK, Omary MB. Ethanol and Acetaminophen Synergistically Induce Hepatic Aggregation and TCH346-Insensitive Nuclear Translocation of GAPDH. PLoS One. 2016 Aug 11;11(8):e0160982. doi: 10.1371/journal.pone.0160982. PMID: 27513663; PMCID: PMC4981434.
