NAGKi | CAS#94825-74-8 | NAGK/NAMK Inhibitor

MedKoo Cat#: 564060 | Name: NAGKi

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NAGKi is an inhibitor of N-acetylglucosamine kinase (NAGK) and N-acetylmannosamine kinase (NAMK).

Chemical Structure

NAGKi

CAS#94825-74-8

Theoretical Analysis

MedKoo Cat#: 564060

Name: NAGKi

CAS#: 94825-74-8

Chemical Formula: C9H17NO6

Exact Mass: 235.1056

Molecular Weight: 235.24

Elemental Analysis: C, 45.95; H, 7.28; N, 5.95; O, 40.81

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 315.00	2 Weeks
10mg	USD 550.00	2 Weeks

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Related CAS #

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Synonym

3-O-Methyl-N-acetyl-D-glucosamine; NAGKi; NAGK-i; NAGK i

IUPAC/Chemical Name

N-[(3R,4R,5S,6R)-2,5-Dihydroxy-6-(hydroxymethyl)-4-methoxyoxan-3-yl]acetamide

InChi Key

SXGSBXSSPNINRW-VARJHODCSA-N

InChi Code

InChI=1S/C9H17NO6/c1-4(12)10-6-8(15-2)7(13)5(3-11)16-9(6)14/h5-9,11,13-14H,3H2,1-2H3,(H,10,12)/t5-,6-,7-,8-,9?/m1/s1

SMILES Code

CC(N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1OC)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

3-O-Methyl-N-acetyl-D-glucosamine is a potent inhibitor of N-acetylglucosamine kinase.

In vitro activity:

During the search for inhibitors of N-acetylneuraminic acid biosynthesis, it was shown that 3-O-methyl-N-acetylglucosamine competitively inhibits the N-acetylglucosamine kinase of rat liver in vitro with a Ki value of 17 microM. N-Acetylmannosamine kinase is inhibited non-competitively with a Ki value of 80 microM. In a human hepatoma cell line (HepG2), 3-O-methyl-N-acetyl-D-glucosamine (1 mM) inhibits the incorporation of 14C-N-acetylglucosamine and 14C-N-acetylmannosamine into cellular glycoproteins by 88% and 70%, respectively. Reference: Eur J Biochem. 1992 Mar 15;204(3):1165-8. https://pubmed.ncbi.nlm.nih.gov/1312935/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 235.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Zeitler R, Giannis A, Danneschewski S, Henk E, Henk T, Bauer C, Reutter W, Sandhoff K. Inhibition of N-acetylglucosamine kinase and N-acetylmannosamine kinase by 3-O-methyl-N-acetyl-D-glucosamine in vitro. Eur J Biochem. 1992 Mar 15;204(3):1165-8. doi: 10.1111/j.1432-1033.1992.tb16743.x. PMID: 1312935.

In vitro protocol:

In vivo protocol:

TBD