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MedKoo Cat#: 576586 | Name: IDX-989

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IDX-989 is an HIV-1 non-nucleoside reverse transcriptase inhibitor.

Chemical Structure

IDX-989
IDX-989
CAS#881924-55-6

Theoretical Analysis

MedKoo Cat#: 576586

Name: IDX-989

CAS#: 881924-55-6

Chemical Formula: C20H16ClFN3O3P

Exact Mass: 431.0602

Molecular Weight: 431.79

Elemental Analysis: C, 55.63; H, 3.74; Cl, 8.21; F, 4.40; N, 9.73; O, 11.12; P, 7.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
IDX-989; IDX 989; IDX989
IUPAC/Chemical Name
Phosphinic acid, P-(2-(aminocarbonyl)-5-chloro-4-fluoro-1H-indol-3-yl)-P-(3-((1E)-2-cyanoethenyl)-5-methylphenyl)-, methyl ester
InChi Key
DFIFLWAAHXINAZ-ONEGZZNKSA-N
InChi Code
1S/C20H16ClFN3O3P/c1-11-8-12(4-3-7-23)10-13(9-11)29(27,28-2)19-16-15(25-18(19)20(24)26)6-5-14(21)17(16)22/h3-6,8-10,25H,1-2H3,(H2,24,26)/b4-3+
SMILES Code
CO[P+]([O-])(c1cc(C)cc(\C=C\C#N)c1)c2c([nH]c3ccc(Cl)c(F)c23)C(=O)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 431.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Zhou XJ, Garner RC, Nicholson S, Kissling CJ, Mayers D. Microdose pharmacokinetics of IDX899 and IDX989, candidate HIV-1 non-nucleoside reverse transcriptase inhibitors, following oral and intravenous administration in healthy male subjects. J Clin Pharmacol. 2009 Dec;49(12):1408-16. doi: 10.1177/0091270009343698. Epub 2009 Sep 23. PMID: 19776293.