GTC365 | CAS#63345-17-5 | hTERT transcriptional repressor

MedKoo Cat#: 561165 | Name: GTC365

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GTC365 is a hTERT transcriptional repressor. GTC365 acts at an early step in the G-quadruplex folding pathway to redirect mutant promoter G-quadruplex misfolding, partially reinstate the correct folding pathway, and reduce hTERT activity through transcriptional repression.

Chemical Structure

GTC365

CAS#63345-17-5

Theoretical Analysis

MedKoo Cat#: 561165

Name: GTC365

CAS#: 63345-17-5

Chemical Formula: C23H24ClN7O4S

Exact Mass:

Molecular Weight: 530.00

Elemental Analysis: C, 52.12; H, 4.56; Cl, 6.69; N, 18.50; O, 12.07; S, 6.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GTC365; GTC-365; GTC 365; NSC177365; NSC-177365; NSC 177365

IUPAC/Chemical Name

2-[3-[[4-[(3-Nitroacridin-9-yl)amino]phenyl]sulfamoyl]propyl]guanidine hydrochloride

InChi Key

OPSGDYHBXKMPNO-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H23N7O4S.ClH/c24-23(25)26-12-3-13-35(33,34)29-16-8-6-15(7-9-16)27-22-18-4-1-2-5-20(18)28-21-14-17(30(31)32)10-11-19(21)22;/h1-2,4-11,14,29H,3,12-13H2,(H,27,28)(H4,24,25,26);1H

SMILES Code

N/C(N)=N\CCCS(=O)(NC1=CC=C(NC2=C(C=CC([N+]([O-])=O)=C3)C3=NC4=CC=CC=C42)C=C1)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 530.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kang HJ, Cui Y, Yin H, Scheid A, Hendricks WP, Schmidt J, Sekulic A, Kong D, Trent JM, Gokhale V, Mao H, Hurley LH. A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters. J Am Chem Soc. 2016 Oct 5. [Epub ahead of print] PubMed PMID: 27643954. 2: Takahashi T, Hara K, Inoue H, Kawa Y, Tokunaga C, Hidayat S, Yoshino K, Kuroda Y, Yonezawa K. Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro. Genes Cells. 2000 Sep;5(9):765-75. Erratum in: Genes Cells 2000 Nov;5(11):949-52. PubMed PMID: 10971657.