IDX-375 | CAS#1256735-81-5 | 1162666-75-2

MedKoo Cat#: 526955 | Name: IDX-375

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IDX-375 is a HCV NS5B polymerase inhibitor potentially for the treatment of HCV infection.

Chemical Structure

IDX-375

CAS#1256735-81-5

Theoretical Analysis

MedKoo Cat#: 526955

Name: IDX-375

CAS#: 1256735-81-5

Chemical Formula: C29H50N5O7PS

Exact Mass:

Molecular Weight: 643.78

Elemental Analysis: C, 54.11; H, 7.83; N, 10.88; O, 17.40; P, 4.81; S, 4.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

IDX-375; IDX 375; IDX375.

IUPAC/Chemical Name

2-hydroxy-N,N,N-trimethylethan-1-aminium 2-(tert-butyl)-1-(3,3-dimethylbutyl)-4-(1-(2-hydroxyethyl)-7-(methylsulfonamido)-1-oxido-4H-benzo[c][1,5,2]diazaphosphinin-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-olate

InChi Key

VARROOBCXLCOQV-UHFFFAOYSA-M

InChi Code

InChI=1S/C24H37N4O6PS.C5H14NO/c1-23(2,3)10-11-28-20(24(4,5)6)19(30)18(22(28)31)21-25-16-9-8-15(27-36(7,33)34)14-17(16)35(32,26-21)13-12-29;1-6(2,3)4-5-7/h8-9,14,20,27,29-30H,10-13H2,1-7H3,(H,25,26,32);7H,4-5H2,1-3H3/q;+1/p-1

SMILES Code

CS(NC1=CC(P(N=C(C2=C([O-])C(C(C)(C)C)N(CCC(C)(C)C)C2=O)N3)(CCO)=O)=C3C=C1)(=O)=O.C[N+](C)(C)CCO

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 1162666-75-2 (IDX-375 free) 1256735-81-5 (IDX-375 salt)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 643.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Valese AC, Vitali L, Fett R, Micke GA, de Oliveira MA, Oliveira Costa AC. A Rapid Method for Analysis of Phenylalanine in Cereal Products by MEKC-UV Using LC/MS/MS as a Comparative Method. J AOAC Int. 2015 Nov-Dec;98(6):1632-9. doi: 10.5740/jaoacint.15-052. PubMed PMID: 26651576. 2: Vitali L, Della Betta F, Costa AC, Vaz FA, Oliveira MA, Vistuba JP, Fávere VT, Micke GA. New multilayer coating using quaternary ammonium chitosan and κ-carrageenan in capillary electrophoresis: application in fast analysis of betaine and methionine. Talanta. 2014 Jun;123:45-53. doi: 10.1016/j.talanta.2014.01.047. PubMed PMID: 24725863. 3: de Bruijne J, van de Wetering de Rooij J, van Vliet AA, Zhou XJ, Temam MF, Molles J, Chen J, Pietropaolo K, Sullivan-Bólyai JZ, Mayers D, Reesink HW. First-in-human study of the pharmacokinetics and antiviral activity of IDX375, a novel nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2012 Aug;56(8):4525-8. doi: 10.1128/AAC.00451-12. PubMed PMID: 22664976; PubMed Central PMCID: PMC3421546.