Synonym
Diclofenac potassium; CGP-45840B; CGP45840B; CGP 45840B
IUPAC/Chemical Name
Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-, monopotassium salt
InChi Key
KXZOIWWTXOCYKR-UHFFFAOYSA-M
InChi Code
InChI=1S/C14H11Cl2NO2.K/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
SMILES Code
O=C([O-])CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl.[K+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
334.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Gan TJ. Diclofenac: an update on its mechanism of action and safety profile. Curr Med Res Opin. 2010 Jul;26(7):1715-31. doi: 10.1185/03007995.2010.486301. PMID: 20470236.
3: Gazal G, Al-Samadani KH. Comparison of paracetamol, ibuprofen, and diclofenac potassium for pain relief following dental extractions and deep cavity preparations. Saudi Med J. 2017 Mar;38(3):284-291. doi: 10.15537/smj.2017.3.16023. PMID: 28251224; PMCID: PMC5387905.
4: Altman R, Bosch B, Brune K, Patrignani P, Young C. Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs. 2015 May;75(8):859-77. doi: 10.1007/s40265-015-0392-z. PMID: 25963327; PMCID: PMC4445819.
5: Tieppo Francio V, Davani S, Towery C, Brown TL. Oral Versus Topical Diclofenac Sodium in the Treatment of Osteoarthritis. J Pain Palliat Care Pharmacother. 2017 Jun;31(2):113-120. doi: 10.1080/15360288.2017.1301616. Epub 2017 Apr 7. PMID: 28388238.
6: Garnock-Jones KP. Diclofenac potassium powder for oral solution: a review of its use in patients with acute migraine. CNS Drugs. 2014 Aug;28(8):761-8. doi: 10.1007/s40263-014-0186-y. PMID: 25034250.
7: Abbas AM, Elzargha AM, Ahmed AGM, Mohamed II, Altraigey A, Abdelbadee AY. Oral Diclofenac Potassium Versus Hyoscine-N-Butyl Bromide in Reducing Pain Perception during Office Hysteroscopy: ARandomized Double-blind Placebo- controlled Trial. J Minim Invasive Gynecol. 2019 May-Jun;26(4):709-716. doi: 10.1016/j.jmig.2018.08.001. Epub 2018 Aug 10. PMID: 30099113.
8: McNeely W, Goa KL. Diclofenac-potassium in migraine: a review. Drugs. 1999 Jun;57(6):991-1003. doi: 10.2165/00003495-199957060-00016. PMID: 10400409.
9: Cigerim L, Eroglu CN. Comparison of Clinical Efficacies of Preoperatively Initiated Naproxen Sodium-Codeine Phosphate in Combination, Diclofenac Potassium, and Benzydamine Hydrochloride for Pain, Edema, and Trismus After Extraction of Impacted Lower Third Molar: A Randomized Double-Blind Study. J Oral Maxillofac Surg. 2018 Mar;76(3):495-502. doi: 10.1016/j.joms.2017.08.041. Epub 2017 Sep 8. PMID: 28961427.
10: Moore N. Diclofenac potassium 12.5mg tablets for mild to moderate pain and fever: a review of its pharmacology, clinical efficacy and safety. Clin Drug Investig. 2007;27(3):163-95. doi: 10.2165/00044011-200727030-00002. PMID: 17305413.
