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MedKoo Cat#: 573726 | Name: Diclofenac sodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.

Chemical Structure

Diclofenac sodium
Diclofenac sodium
CAS#15307-79-6 (sodium)

Theoretical Analysis

MedKoo Cat#: 573726

Name: Diclofenac sodium

CAS#: 15307-79-6 (sodium)

Chemical Formula: C14H10Cl2NNaO2

Exact Mass: 316.9986

Molecular Weight: 318.13

Elemental Analysis: C, 52.86; H, 3.17; Cl, 22.29; N, 4.40; Na, 7.23; O, 10.06

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 weeks
25g USD 450.00 2 weeks
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Related CAS #
81811-14-5 (deanol) 119623-66-4 (epolamine) 15307-86-5 (free acid) 15307-79-6 (sodium) 15307-81-0 (Potassium) 78213-16-8 (diethylamine) 64118-81-6 (Acyl Glucuronide)
Synonym
Abitren, Allvoran, Assaren, Batafil, Berifen, Blesin, Delimon, Delphimix, Diclofenac sodium, Neriodin, Orthophen, Sodium diclofenac, Voltaren, Voltaren-XR, Voltarene, Voltarol
IUPAC/Chemical Name
Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-, monosodium salt
InChi Key
KPHWPUGNDIVLNH-UHFFFAOYSA-M
InChi Code
1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
SMILES Code
c1ccc(c(c1)CC(=O)[O-])Nc2c(cccc2Cl)Cl.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 318.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liao AH, Chuang HC, Chung HY. Efficacy of ultrasound mediated microbubbles in diclofenac gel to enhance transdermal permeation in rheumatoid arthritis induced rat. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:3521-3524. PubMed PMID: 26737052. 2: Zupanets IA, Shebeko SK, Popov OS, Shalamay AS. Diclocor is superior to diclofenac sodium and quercetin in normalizing biochemical parameters in rats with collagen-induced osteoarthritis. Inflammopharmacology. 2016 Jan 5. [Epub ahead of print] PubMed PMID: 26732579. 3: Winkler S, Springorum HR, Vaitl T, Handel M, Barta S, Kehl V, Craiovan B, Grifka J. Comparative clinical study of the prophylaxis of heterotopic ossifications after total hip arthroplasty using etoricoxib or diclofenac. Int Orthop. 2016 Jan 4. [Epub ahead of print] PubMed PMID: 26728611. 4: Bashir MU, Qureshi HJ, Saleem T. COMPARISON OF ANTI-INFLAMMATORY ACTIVITY OF NIGELLA SATIVA AND DICLOFENAC SODIUM IN ALBINO RATS. J Ayub Med Coll Abbottabad. 2015 Jul-Sep;27(3):523-6. PubMed PMID: 26720998. 5: Di Nardo G, Dell'Angelo V, Catucci G, Sadeghi SJ, Gilardi G. Subtle structural changes in the Asp251Gly/Gln307His P450 BM3 mutant responsible for new activity toward diclofenac, tolbutamide and ibuprofen. Arch Biochem Biophys. 2015 Dec 21. pii: S0003-9861(15)30116-8. doi: 10.1016/j.abb.2015.12.005. [Epub ahead of print] PubMed PMID: 26718083. 6: Zhang Y, Han YH, Putluru SP, Matta MK, Kole P, Mandlekar S, Furlong MT, Liu T, Iyer RA, Marathe P, Yang Z, Lai Y, Rodrigues DA. Diclofenac and its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro. Drug Metab Dispos. 2015 Dec 29. pii: dmd.115.066944. [Epub ahead of print] PubMed PMID: 26714763. 7: Jeter JM, Curiel-Lewandrowski C, Stratton SP, Myrdal PB, Warneke JA, Einspahr JG, Bartels H, Yozwiak M, Bermudez Y, Hu C, Bartels P, Alberts DS. Phase IIB Randomized Study of Topical Difluoromethylornithine and Topical Diclofenac on Sun-Damaged Skin of the Forearm. Cancer Prev Res (Phila). 2015 Dec 28. pii: canprevres.0232.2015. [Epub ahead of print] PubMed PMID: 26712942. 8: Peyghambari F, Dashti-Rahmatabadi MH, Rozabadi MD, Rozabadi RD, Rozabadi FD, Pangalizadeh M, Dehghanimohammadabadi N. Antinociceptive effect of palm date spathe hydroalcoholic extract on acute and chronic pain in mice as compared with analgesic effect of morphine and diclofenac. Adv Biomed Res. 2015 Nov 23;4:244. doi: 10.4103/2277-9175.170239. eCollection 2015. PubMed PMID: 26693469; PubMed Central PMCID: PMC4685642. 9: Woode E, Ameyaw EO, Abotsi WK, Boakye-Gyasi E. An isobolographic analysis of the antinociceptive effect of xylopic acid in combination with morphine or diclofenac. J Basic Clin Pharm. 2015 Sep;6(4):103-8. doi: 10.4103/0976-0105.168055. PubMed PMID: 26692735; PubMed Central PMCID: PMC4660480. 10: Jauris IM, Matos CF, Saucier C, Lima EC, Zarbin AJ, Fagan SB, Machado FM, Zanella I. Adsorption of sodium diclofenac on graphene: a combined experimental and theoretical study. Phys Chem Chem Phys. 2015 Dec 15. [Epub ahead of print] PubMed PMID: 26671178.