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MedKoo Cat#: 412401 | Name: Carsatrin succinate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carsatrin succinate is the salt form on Carsatin, a purinylpiperazine derivative patented by Ortho Pharmaceutical Corp. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+,K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbine, or prazosin

Chemical Structure

Carsatrin succinate
Carsatrin succinate
CAS#132199-13-4 (salt)

Theoretical Analysis

MedKoo Cat#: 412401

Name: Carsatrin succinate

CAS#: 132199-13-4 (salt)

Chemical Formula: C29H32F2N6O5S

Exact Mass:

Molecular Weight: 614.67

Elemental Analysis: C, 56.67; H, 5.25; F, 6.18; N, 13.67; O, 13.01; S, 5.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
412400 (free base) 132199-13-4 (salt)
Synonym
Carsatrin succinate; RWJ24517; RWJ-24517; RWJ 24517
IUPAC/Chemical Name
1-Piperazineethanol, 4-(bis(4-fluorophenyl)methyl)-alpha-((9H-purin-6-ylthio)methyl)-, (+-)-, butanedioate (1:1) (salt)
InChi Key
HITUQCDKZKCYIZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H26F2N6OS.C4H6O4/c26-19-5-1-17(2-6-19)23(18-3-7-20(27)8-4-18)33-11-9-32(10-12-33)13-21(34)14-35-25-22-24(29-15-28-22)30-16-31-25;5-3(6)1-2-4(7)8/h1-8,15-16,21,23,34H,9-14H2,(H,28,29,30,31);1-2H2,(H,5,6)(H,7,8)
SMILES Code
OC(CSC1=C2N=CNC2=NC=N1)CN3CCN(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3.O=C(O)CCC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 614.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Press JB, Falotico R, Hajos ZG, Sawyers RA, Kanojia RM, Williams L, Haertlein B, Kauffman JA, Lakas-Weiss C, Salata JJ. Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes. J Med Chem. 1992 Nov 27;35(24):4509-15. doi: 10.1021/jm00102a001. PMID: 1335073. 2: Tsushima RG, Kelly JE, Salata JJ, Liberty KN, Wasserstrom JA. Modification of cardiac Na(+) current by RWJ 24517 and its enantiomers in guinea pig ventricular myocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):845-55. PMID: 10525108. 3: Krafte DS, Davison K, Dugrenier N, Estep K, Josef K, Barchi RL, Kallen RG, Silver PJ, Ezrin AM. Pharmacological modulation of human cardiac Na+ channels. Eur J Pharmacol. 1994 Feb 15;266(3):245-54. doi: 10.1016/0922-4106(94)90133-3. PMID: 8174607. 4: Kawamura A, Wahler GM, Solaro RJ. RWJ-24517, a positive inotropic agent, has novel effects on action potentials in guinea pig myocardium. J Cardiovasc Pharmacol. 1993 Oct;22(4):519-25. doi: 10.1097/00005344-199310000-00003. PMID: 7505352.