Synonym
Benzyl Cinnamate; Cinnamein; Benzyl 3-phenylpropenoate; Cinnamic acid benzyl ester;
IUPAC/Chemical Name
benzyl (E)-3-phenylprop-2-enoate
InChi Key
NGHOLYJTSCBCGC-VAWYXSNFSA-N
InChi Code
1S/C16H14O2/c17-16(12-11-14-7-3-1-4-8-14)18-13-15-9-5-2-6-10-15/h1-12H,13H2/b12-11+
SMILES Code
O=C(OCC1=CC=CC=C1)/C=C/C2=CC=CC=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
238.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cao YP, Zhi GY, Han L, Chen Q, Zhang DH. Biosynthesis of benzyl cinnamate using an efficient immobilized lipase entrapped in nano-molecular cages. Food Chem. 2021 Dec 1;364:130428. doi: 10.1016/j.foodchem.2021.130428. Epub 2021 Jun 19. PMID: 34182366.
2: Piazza SP, Puton BM, Dallago RM, de Oliveira D, Cansian RL, Mignoni M, Paroul N. Production of benzyl cinnamate by a low-cost immobilized lipase and evaluation of its antioxidant activity and toxicity. Biotechnol Rep (Amst). 2021 Jan 6;29:e00586. doi: 10.1016/j.btre.2021.e00586. PMID: 33489787; PMCID: PMC7809389.
3: Bhatia SP, Wellington GA, Cocchiara J, Lalko J, Letizia CS, Api AM. Fragrance material review on benzyl cinnamate. Food Chem Toxicol. 2007;45 Suppl 1:S40-8. doi: 10.1016/j.fct.2007.09.027. Epub 2007 Sep 14. PMID: 18037214.
4: Wang Y, Zhang DH, Chen N, Zhi GY. Synthesis of benzyl cinnamate by enzymatic esterification of cinnamic acid. Bioresour Technol. 2015 Dec;198:256-61. doi: 10.1016/j.biortech.2015.09.028. Epub 2015 Sep 16. PMID: 26398669.
5: Zhang DH, Zhang JY, Che WC, Wang Y. A new approach to synthesis of benzyl cinnamate: Optimization by response surface methodology. Food Chem. 2016 Sep 1;206:44-9. doi: 10.1016/j.foodchem.2016.03.015. Epub 2016 Mar 7. PMID: 27041296.
6: Sun S, Tian L. Novozym 40086 as a novel biocatalyst to improve benzyl cinnamate synthesis. RSC Adv. 2018 Nov 5;8(65):37184-37192. doi: 10.1039/c8ra08433e. PMID: 35557827; PMCID: PMC9089159.
7: Walgrave SE, Warshaw EM, Glesne LA. Allergic contact dermatitis from propolis. Dermatitis. 2005 Dec;16(4):209-15. PMID: 16536336.
8: EISENSTEIN MI, BENDO GJ. Treatment of chronic salpingitis with benzyl cinnamate ester (Jacobson's solution). Am J Surg. 1947 Aug;74(2):200-4. doi: 10.1016/0002-9610(47)90164-5. PMID: 20252991.
