MedKoo Cat#: 208266 | Name: NPD4928
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NPD4928 enhanced the sensitivity of various cancer cells to GPX4 inhibitors, suggesting that the combination might have therapeutic potential via the induction of ferroptosis.

Chemical Structure

NPD4928
NPD4928
CAS#956965-61-0

Theoretical Analysis

MedKoo Cat#: 208266

Name: NPD4928

CAS#: 956965-61-0

Chemical Formula: C29H32N2O6

Exact Mass: 504.2260

Molecular Weight: 504.58

Elemental Analysis: C, 69.03; H, 6.39; N, 5.55; O, 19.02

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,450.00 2 Weeks
500mg USD 3,250.00 2 Weeks
1g USD 4,950.00 2 Weeks
2g USD 7,450.00 2 Weeks
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Related CAS #
No Data
Synonym
NPD4928, NPD-4928, NPD 4928
IUPAC/Chemical Name
N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)-2-((3,4,8,8-tetramethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-5-yl)oxy)acetamide
InChi Key
ZDCXTKTVNQLRGC-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H32N2O6/c1-16-17(2)28(33)36-27-20-8-10-29(3,4)37-23(20)13-24(26(16)27)35-15-25(32)30-11-9-18-14-31-22-7-6-19(34-5)12-21(18)22/h6-7,12-14,31H,8-11,15H2,1-5H3,(H,30,32)
SMILES Code
COC1=CC=C2C(C(CCNC(COC3=CC(OC(C)(C)CC4)=C4C(O5)=C3C(C)=C(C)C5=O)=O)=CN2)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 504.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H. Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1). ACS Chem Biol. 2022 Feb 18;17(2):483-491. doi: 10.1021/acschembio.2c00028. Epub 2022 Feb 7. PMID: 35128925.