JR-AB2-000 is a novel potent inhibitor of mTORC2 kinase activity, specifically inhibiting phosphorylation of mTORC2 substrates, including AKT (Ser-473), NDRG1 (Thr-346) and PKCa (Ser-657), while having no appreciable effects on the phosphorylation status of the mTORC1 substrate S6K (Thr-389) or mTORC1-dependent negative feedback loops.
MedKoo Cat#: 463327
Name: JR-AB2-000
CAS#: unknown
Chemical Formula: C19H19Cl2N3OS
Exact Mass: 407.0626
Molecular Weight: 408.34
Elemental Analysis: C, 55.89; H, 4.69; Cl, 17.36; N, 10.29; O, 3.92; S, 7.85
The following data is based on the product molecular weight 408.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1155.jpg "N-Linoleoyl-DPPE (ammonium salt)")
