R-(+)-EU-1180-453 is a second-generation GluN2C/D-selective NMDAR-positive allosteric modulators (PAMs). It exhibits log unit improvements in the concentration needed to double receptor response, lipophilic efficiency, and aqueous solubility, and lowers cLogP by one log unit compared to the first-generation prototype CIQ. Additionally, R-(+)-EU-1180-453 was found to increase glutamate potency 2-fold, increase the response to maximally effective concentration of agonist 4-fold, and the racemate is brain-penetrant.
MedKoo Cat#: 462373
Name: EU-1180-453
CAS#: 2488764-06-1 (R-isomer)
Chemical Formula: 380.1536
Exact Mass: 380.1536
Molecular Weight: 380.42
Elemental Analysis: C, 69.46; H, 5.56; F, 4.99; N, 7.36; O, 12.62
The following data is based on the product molecular weight 380.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
