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MedKoo Cat#: 565634 | Name: UCB-H

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UCB-H is a potent ligand of the synaptic vesicle protein 2a (sv2a) protein

Chemical Structure

UCB-H
UCB-H
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565634

Name: UCB-H

CAS#: N/A

Chemical Formula: C16H12F4N2O

Exact Mass: 324.0886

Molecular Weight: 324.28

Elemental Analysis: C, 59.26; H, 3.73; F, 23.43; N, 8.64; O, 4.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
UCB-H; UCB H; UCBH
IUPAC/Chemical Name
1-((3-Fluoropyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one
InChi Key
KNDCJGAPPBQUTQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H12F4N2O/c17-12-3-10(4-13(18)16(12)20)11-5-15(23)22(8-11)7-9-1-2-21-6-14(9)19/h1-4,6,11H,5,7-8H2
SMILES Code
O=C1N(CC2=C(F)C=NC=C2)CC(C3=CC(F)=C(F)C(F)=C3)C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 324.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Serrano ME, Becker G, Bahri MA, Seret A, Mestdagh N, Mercier J, Mievis F, Giacomelli F, Lemaire C, Salmon E, Luxen A, Plenevaux A. Evaluating the In Vivo Specificity of [(18)F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET. Molecules. 2019 May 1;24(9). pii: E1705. doi: 10.3390/molecules24091705. PubMed PMID: 31052478; PubMed Central PMCID: PMC6538996. 2: Serrano ME, Bahri MA, Becker G, Seret A, Mievis F, Giacomelli F, Lemaire C, Salmon E, Luxen A, Plenevaux A. Quantification of [(18)F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value. Mol Imaging Biol. 2018 Nov 20. doi: 10.1007/s11307-018-1301-0. [Epub ahead of print] PubMed PMID: 30460626. 3: Constantinescu CC, Tresse C, Zheng M, Gouasmat A, Carroll VM, Mistico L, Alagille D, Sandiego CM, Papin C, Marek K, Seibyl JP, Tamagnan GD, Barret O. Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers. Mol Imaging Biol. 2019 Jun;21(3):509-518. doi: 10.1007/s11307-018-1260-5. PubMed PMID: 30084043. 4: Mercier J, Provins L, Valade A. Discovery and development of SV2A PET tracers: Potential for imaging synaptic density and clinical applications. Drug Discov Today Technol. 2017 Nov;25:45-52. doi: 10.1016/j.ddtec.2017.11.003. Epub 2017 Dec 1. Review. PubMed PMID: 29233267. 5: Bahri MA, Plenevaux A, Aerts J, Bastin C, Becker G, Mercier J, Valade A, Buchanan T, Mestdagh N, Ledoux D, Seret A, Luxen A, Salmon E. Measuring brain synaptic vesicle protein 2A with positron emission tomography and [(18)F]UCB-H. Alzheimers Dement (N Y). 2017 Aug 30;3(4):481-486. doi: 10.1016/j.trci.2017.08.004. eCollection 2017 Nov. PubMed PMID: 29124105; PubMed Central PMCID: PMC5671624. 6: Becker G, Warnier C, Serrano ME, Bahri MA, Mercier J, Lemaire C, Salmon E, Luxen A, Plenevaux A. Pharmacokinetic Characterization of [(18)F]UCB-H PET Radiopharmaceutical in the Rat Brain. Mol Pharm. 2017 Aug 7;14(8):2719-2725. doi: 10.1021/acs.molpharmaceut.7b00235. Epub 2017 Jul 13. PubMed PMID: 28651055. 7: Warnier C, Lemaire C, Becker G, Zaragoza G, Giacomelli F, Aerts J, Otabashi M, Bahri MA, Mercier J, Plenevaux A, Luxen A. Enabling Efficient Positron Emission Tomography (PET) Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) with a Robust and One-Step Radiosynthesis of a Highly Potent (18)F-Labeled Ligand ([(18)F]UCB-H). J Med Chem. 2016 Oct 13;59(19):8955-8966. Epub 2016 Sep 20. PubMed PMID: 27598384. 8: Bretin F, Bahri MA, Bernard C, Warnock G, Aerts J, Mestdagh N, Buchanan T, Otoul C, Koestler F, Mievis F, Giacomelli F, Degueldre C, Hustinx R, Luxen A, Seret A, Plenevaux A, Salmon E. Biodistribution and Radiation Dosimetry for the Novel SV2A Radiotracer [(18)F]UCB-H: First-in-Human Study. Mol Imaging Biol. 2015 Aug;17(4):557-64. doi: 10.1007/s11307-014-0820-6. PubMed PMID: 25595813. 9: Warnock GI, Aerts J, Bahri MA, Bretin F, Lemaire C, Giacomelli F, Mievis F, Mestdagh N, Buchanan T, Valade A, Mercier J, Wood M, Gillard M, Seret A, Luxen A, Salmon E, Plenevaux A. Evaluation of 18F-UCB-H as a novel PET tracer for synaptic vesicle protein 2A in the brain. J Nucl Med. 2014 Aug;55(8):1336-41. doi: 10.2967/jnumed.113.136143. Epub 2014 Jun 16. PubMed PMID: 24935992. 10: Mercier J, Archen L, Bollu V, Carré S, Evrard Y, Jnoff E, Kenda B, Lallemand B, Michel P, Montel F, Moureau F, Price N, Quesnel Y, Sauvage X, Valade A, Provins L. Discovery of heterocyclic nonacetamide synaptic vesicle protein 2A (SV2A) ligands with single-digit nanomolar potency: opening avenues towards the first SV2A positron emission tomography (PET) ligands. ChemMedChem. 2014 Apr;9(4):693-8. doi: 10.1002/cmdc.201300482. Epub 2014 Jan 20. PubMed PMID: 24446373. 11: Bretin F, Warnock G, Bahri MA, Aerts J, Mestdagh N, Buchanan T, Valade A, Mievis F, Giacomelli F, Lemaire C, Luxen A, Salmon E, Seret A, Plenevaux A. Preclinical radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H. EJNMMI Res. 2013 May 7;3(1):35. doi: 10.1186/2191-219X-3-35. PubMed PMID: 23647774; PubMed Central PMCID: PMC3655042.