Sydowinin B is a xanthone polyketide that has been found in A. sydowii and has immunosuppressant activity. It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 19.2 and 20.8 µg/ml, respectively). Sydowinin B inhibits superoxide generation in, and elastase release from, isolated human neutrophils induced by cytochalasin B and fMLP with IC50 values of 21.2 and 12.62 µM, respectively.
MedKoo Cat#: 534794
Name: Sydowinin B
CAS#: 58450-00-3
Chemical Formula: C16H12O7
Exact Mass: 316.0583
Molecular Weight: 316.27
Elemental Analysis: C, 60.76; H, 3.82; O, 35.41
The following data is based on the product molecular weight 316.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
