GSK8470 HCl | CAS#N/A

MedKoo Cat#: 533331 | Name: GSK8470 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK8470 is a novel agonist of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2).

Chemical Structure

GSK8470 HCl

CAS#GSK8470 HCl

Theoretical Analysis

MedKoo Cat#: 533331

Name: GSK8470 HCl

CAS#: GSK8470 HCl

Chemical Formula: C28H36ClN

Exact Mass: 385.2770

Molecular Weight: 422.05

Elemental Analysis: C, 79.68; H, 8.60; Cl, 8.40; N, 3.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1276664-65-3 (free base) GSK8470 HCl

Synonym

GSK8470; GSK-8470; GSK 8470; GSK8470 HCl; GSK8470 hydrochloride

IUPAC/Chemical Name

(3aS,6aR)-5-[(E)-Oct-4-en-4-yl]-N,4-diphenyl-2,3,6,6a-tetrahydro-1H-pentalen-3a-amine hydrochloride

InChi Key

LLXLBGUBGYQHFK-GSMOMSSOSA-N

InChi Code

InChI=1S/C28H35N.ClH/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23;/h6-11,14-16,18-19,24,29H,3-5,12-13,17,20-21H2,1-2H3;1H/b22-14+;/t24-,28+;/m1./s1

SMILES Code

CCC/C(C1=C(C2=CC=CC=C2)[C@]3(NC4=CC=CC=C4)CCC[C@]3([H])C1)=C\CCC.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 422.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec J, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA. Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists. J Biol Chem. 2016 Dec 2;291(49):25281-25291. doi: 10.1074/jbc.M116.753541. Epub 2016 Sep 30. PMID: 27694446; PMCID: PMC5207232. 2: Whitby RJ, Dixon S, Maloney PR, Delerive P, Goodwin BJ, Parks DJ, Willson TM. Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1. J Med Chem. 2006 Nov 16;49(23):6652-5. doi: 10.1021/jm060990k. PMID: 17154495.