ALW-II-49-7, also known as DDR2-IN-1, is a potent DDR2 Inhibitor for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer. ALW-II-49-7 targets DDR2 and DDR1. Other targets of ALW-II-49-7 are RAF1 and LYN. ALW-II-49-7 shows antiproliferative activity against DDR2-mutated lung cancer cell lines NCI-H2286 and HCC-366.
MedKoo Cat#: 465020
Name: ALW-II-49-7
CAS#: 1135219-23-6 (free base)
Chemical Formula: C21H17F3N4O2
Exact Mass: 414.1304
Molecular Weight: 414.39
Elemental Analysis: C, 60.87; H, 4.14; F, 13.75; N, 13.52; O, 7.72
The following data is based on the product molecular weight 414.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
