Synonym
Ganodermanondiol; ( )-Ganodermanondiol;
IUPAC/Chemical Name
(5R,10S,13R,14R,17R)-17-((2R,5S)-5,6-dihydroxy-6-methylheptan-2-yl)-4,4,10,13,14-pentamethyl-1,2,4,5,6,10,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
InChi Key
AAJIHHYEPHRIET-XEFAKFPISA-N
InChi Code
InChI=1S/C30H48O3/c1-19(9-12-25(32)27(4,5)33)20-13-17-30(8)22-10-11-23-26(2,3)24(31)15-16-28(23,6)21(22)14-18-29(20,30)7/h10,14,19-20,23,25,32-33H,9,11-13,15-18H2,1-8H3/t19-,20-,23+,25+,28-,29-,30+/m1/s1
SMILES Code
CC1(C)C(CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C)CC[C@H](O)C(C)(O)C)CC[C@](C)4C3=CC[C@@]12[H])=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
456.71
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Li B, Lee DS, Kang Y, Yao NQ, An RB, Kim YC. Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes. Food Chem Toxicol. 2013 Mar;53:317-24. doi: 10.1016/j.fct.2012.12.016. Epub 2012 Dec 21. PubMed PMID: 23266269.
2: Kim JW, Kim HI, Kim JH, Kwon OC, Son ES, Lee CS, Park YJ. Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum. Int J Mol Sci. 2016 Oct 27;17(11). pii: E1798. PubMed PMID: 27801787; PubMed Central PMCID: PMC5133799.
3: Li P, Deng YP, Wei XX, Xu JH. Triterpenoids from Ganoderma lucidum and their cytotoxic activities. Nat Prod Res. 2013;27(1):17-22. doi: 10.1080/14786419.2011.652961. Epub 2012 Jan 20. PubMed PMID: 22263904.
4: Gao JJ, Min BS, Ahn EM, Nakamura N, Lee HK, Hattori M. New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells. Chem Pharm Bull (Tokyo). 2002 Jun;50(6):837-40. PubMed PMID: 12045343.
5: Dai J, Miller MA, Everetts NJ, Wang X, Li P, Li Y, Xu JH, Yao G. Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum. Oncotarget. 2017 Feb 21;8(8):13770-13781. doi: 10.18632/oncotarget.14634. PubMed PMID: 28099150; PubMed Central PMCID: PMC5355137.
6: Mendoza G, Suárez-Medellín J, Espinoza C, Ramos-Ligonio A, Fernández JJ, Norte M, Trigos Á. Isolation and Characterization of Bioactive Metabolites from Fruiting Bodies and Mycelial Culture of Ganoderma oerstedii (Higher Basidiomycetes) from Mexico. Int J Med Mushrooms. 2015;17(6):501-9. PubMed PMID: 26349508.
7: Min BS, Gao JJ, Hattori M, Lee HK, Kim YH. Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. Planta Med. 2001 Dec;67(9):811-4. PubMed PMID: 11745016.
8: Min BS, Nakamura N, Miyashiro H, Bae KW, Hattori M. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1607-12. PubMed PMID: 9810695.
9: Zheng DS, Chen LS. Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Exp Ther Med. 2017 Oct;14(4):3273-3278. doi: 10.3892/etm.2017.4883. Epub 2017 Aug 3. PubMed PMID: 28912878; PubMed Central PMCID: PMC5585879.
