MD001 | CAS# 2254605-76-8 | Dual Agonist

MedKoo Cat#: 574024 | Name: MD001

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ. It binds to PPARα and PPARγ but does not bind to PPARβ/δ. It increases transcriptional activity of PPARα and PPARγ and glucose consumption. MD001 decreases levels of glucose, insulin, free fatty acids, triglycerides, LDL, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in blood and reduces the size and number of hepatic lipid droplets in diabetic db/db mice.

Chemical Structure

MD001

CAS#2254605-76-8

Theoretical Analysis

MedKoo Cat#: 574024

Name: MD001

CAS#: 2254605-76-8

Chemical Formula: C25H18O5

Exact Mass: 398.1154

Molecular Weight: 398.41

Elemental Analysis: C, 75.37; H, 4.55; O, 20.08

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 750.00	2 weeks

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Synonym

MD001, MD 001; MD-001

IUPAC/Chemical Name

5,7-dihydroxy-8-methyl-3-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]-4-phenyl-2H-1-benzopyran-2-one

InChi Key

RTYVORPNMMHKDM-OUKQBFOZSA-N

InChi Code

InChI=1S/C25H18O5/c1-15-19(27)14-20(28)22-21(17-10-6-3-7-11-17)23(25(29)30-24(15)22)18(26)13-12-16-8-4-2-5-9-16/h2-14,27-28H,1H3/b13-12+

SMILES Code

O=C(C1=C(C2=CC=CC=C2)C3=C(C(C)=C(O)C=C3O)OC1=O)/C=C/C4=CC=CC=C4

Appearance

Solid powder

Purity

>90% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.

In vitro activity:

Only MD001 functions as a PPARα/γ dual agonist in vitro. MD001 increased the transcriptional activity of PPARα and PPARγ, resulting in enhanced expression of genes related to β-oxidation and fatty acid and glucose uptake. Reference: Sci Rep. 2019 Feb 7;9(1):1656. https://pubmed.ncbi.nlm.nih.gov/30733541/

In vivo activity:

MD001 significantly improved blood metabolic parameters, including triglycerides, free fatty acids, and glucose, in db/db mice. In addition, MD001 ameliorated hepatic steatosis by stimulating β-oxidation in vitro and in vivo. Reference: Sci Rep. 2019 Feb 7;9(1):1656. https://pubmed.ncbi.nlm.nih.gov/30733541/

	Solvent	mg/mL	mM
Solubility
	DMF	30.0	75.30
	DMSO	30.0	75.30
	Ethanol	20.0	50.20

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 398.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Kim SH, Hong SH, Park YJ, Sung JH, Suh W, Lee KW, Jung K, Lim C, Kim JH, Kim H, Park KS, Park SG. MD001, a Novel Peroxisome Proliferator-activated Receptor α/γ Agonist, Improves Glucose and Lipid Metabolism. Sci Rep. 2019 Feb 7;9(1):1656. doi: 10.1038/s41598-018-38281-0. PMID: 30733541; PMCID: PMC6367362.

In vitro protocol:

In vivo protocol:

1. Kim, S.-H., Hong, S.H., Park, Y.-J., et al. MD001, a novel peroxisome proliferator-activated receptor α/γ agonist, improves glucose and lipid metabolism. Sci. Rep. 9(1), 1656 (2019).